======= ATP8B3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP8B3
  * **<color #00a2e8>Official Name</color>**: ATPase phospholipid transporting 8B3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=148229|148229]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60423|O60423]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATP8B3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATP8B3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605866|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes. Involved in acrosome reactions and binding of spermatozoa to zona pellucida. {ECO:0000250|UniProtKB:Q6UQ17}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HAD|
|E1-E2 ATPase|
|Hydrolase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ATPase-coupled intramembrane lipid transporter activity|
|acrosomal membrane|
|binding of sperm to zona pellucida|
|phospholipid translocation|
|lipid translocation|
|sperm-egg recognition|
|regulation of membrane lipid distribution|
|cell-cell recognition|
|phospholipid transport|
|organophosphate ester transport|
|Golgi organization|
|single fertilization|
|fertilization|
|magnesium ion binding|
|cell recognition|
|lipid transport|
|lipid localization|
|endomembrane system organization|
|organic anion transport|
|anion transport|
|sexual reproduction|
|membrane organization|
|endoplasmic reticulum membrane|
|Golgi apparatus|
|multi-organism reproductive process|
|ion transport|
|reproductive process|
|reproduction|
|ATP binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.93|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.91|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.75|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.7|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2423
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATP8B3 Expression in NALM6 Cells: 4.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>