======= ATR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATR
  * **<color #00a2e8>Official Name</color>**: ATR serine/threonine kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=545|545]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13535|Q13535]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601215|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication. {ECO:0000269|PubMed:10597277, ECO:0000269|PubMed:10608806, ECO:0000269|PubMed:10859164, ECO:0000269|PubMed:11114888, ECO:0000269|PubMed:11418864, ECO:0000269|PubMed:11673449, ECO:0000269|PubMed:11721054, ECO:0000269|PubMed:11865061, ECO:0000269|PubMed:12526805, ECO:0000269|PubMed:12791985, ECO:0000269|PubMed:12814551, ECO:0000269|PubMed:14657349, ECO:0000269|PubMed:14729973, ECO:0000269|PubMed:14742437, ECO:0000269|PubMed:15210935, ECO:0000269|PubMed:15314022, ECO:0000269|PubMed:15496423, ECO:0000269|PubMed:16260606, ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:27723717, ECO:0000269|PubMed:27723720, ECO:0000269|PubMed:9427750, ECO:0000269|PubMed:9636169, ECO:0000269|PubMed:9925639}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FAT|
|FATC|
|PI3 PI4 kinase|
|UME|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|establishment of RNA localization to telomere|
|establishment of protein-containing complex localization to telomere|
|positive regulation of telomerase catalytic core complex assembly|
|regulation of telomerase catalytic core complex assembly|
|MutSalpha complex binding|
|MutLalpha complex binding|
|establishment of protein localization to telomere|
|replicative senescence|
|establishment of protein localization to chromosome|
|protein localization to chromosome, telomeric region|
|positive regulation of DNA damage response, signal transduction by p53 class mediator|
|positive regulation of signal transduction by p53 class mediator|
|cellular response to gamma radiation|
|regulation of DNA damage response, signal transduction by p53 class mediator|
|positive regulation of telomere maintenance via telomerase|
|positive regulation of telomere maintenance via telomere lengthening|
|negative regulation of DNA replication|
|positive regulation of telomere maintenance|
|interstrand cross-link repair|
|regulation of telomere maintenance via telomerase|
|response to gamma radiation|
|regulation of telomere maintenance via telomere lengthening|
|protein localization to chromosome|
|cell aging|
|positive regulation of DNA biosynthetic process|
|cellular response to ionizing radiation|
|regulation of cellular response to heat|
|regulation of telomere maintenance|
|cellular response to UV|
|positive regulation of response to DNA damage stimulus|
|telomere maintenance|
|PML body|
|telomere organization|
|regulation of DNA replication|
|nuclear chromosome, telomeric region|
|regulation of DNA biosynthetic process|
|cellular response to light stimulus|
|chromosome|
|DNA damage checkpoint|
|response to UV|
|DNA integrity checkpoint|
|response to ionizing radiation|
|positive regulation of chromosome organization|
|cellular response to radiation|
|peptidyl-serine phosphorylation|
|regulation of signal transduction by p53 class mediator|
|protein autophosphorylation|
|cell cycle checkpoint|
|positive regulation of DNA metabolic process|
|establishment of RNA localization|
|peptidyl-serine modification|
|DNA replication|
|RNA localization|
|regulation of response to DNA damage stimulus|
|protein kinase activity|
|positive regulation of protein complex assembly|
|protein-containing complex localization|
|aging|
|response to light stimulus|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|anatomical structure homeostasis|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|protein serine/threonine kinase activity|
|establishment of protein localization to organelle|
|response to radiation|
|regulation of protein complex assembly|
|DNA repair|
|positive regulation of cellular component biogenesis|
|negative regulation of cell cycle|
|positive regulation of organelle organization|
|regulation of cellular response to stress|
|protein localization to organelle|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|peptidyl-amino acid modification|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|Golgi apparatus|
|response to drug|
|positive regulation of intracellular signal transduction|
|chromosome organization|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|phosphorylation|
|regulation of organelle organization|
|negative regulation of cellular macromolecule biosynthetic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|homeostatic process|
|positive regulation of signal transduction|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.75|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.49|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.15|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.91|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.85|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 278/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|15/28|
|blood|10/28|
|bone|13/26|
|breast|17/33|
|central nervous system|21/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|3/13|
|fibroblast|1/1|
|gastric|8/16|
|kidney|6/21|
|liver|9/20|
|lung|30/75|
|lymphocyte|3/16|
|ovary|8/26|
|pancreas|6/24|
|peripheral nervous system|7/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|10/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|5/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 677
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATR Expression in NALM6 Cells: 7.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>