======= AUP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AUP1
  * **<color #00a2e8>Official Name</color>**: AUP1 lipid droplet regulating VLDL assembly factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=550|550]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y679|Q9Y679]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AUP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AUP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602434|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded this gene is involved in several pathways including quality control of misfolded proteins in the endoplasmic reticulum and lipid droplet accumulation. Lipid droplets are organelles in the cytoplasm that store neutral lipids such as cholesterol esters and trigylycerides to prevent the overabundance of free cholesterol and fatty acids in cells, but also to act as storage for other metabolic processes, such as membrane biogenesis. Reduced expression of this gene results in reduced lipid droplet clustering, a function that is dependent on ubiquitination of the protein. This protein contains multiple domains including a hydrophobic N-terminal domain, an acetyltranferase domain, a ubiquitin-binding CUE domain, and a UBE2B2-binding domain (G2BR). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. {ECO:0000269|PubMed:18711132}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CUE|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Hrd1p ubiquitin ligase ERAD-L complex|
|ubiquitin-protein transferase activator activity|
|retrograde protein transport, ER to cytosol|
|endoplasmic reticulum to cytosol transport|
|protein exit from endoplasmic reticulum|
|ubiquitin-dependent ERAD pathway|
|ubiquitin binding|
|ERAD pathway|
|integral component of endoplasmic reticulum membrane|
|response to endoplasmic reticulum stress|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|response to organonitrogen compound|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|proteolysis|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-2.47|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.37|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.37|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.25|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.2|
|[[:results:exp453|B02 10μM R08 exp453]]|-2.04|
|[[:results:exp539|42°C R08 exp539]]|1.76|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.81|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.82|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.92|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.97|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|2|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.21|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.55|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.84|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|3.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:ube2g2|UBE2G2]]|0.599|
|[[:human genes:m:manf|MANF]]|0.484|
|[[:human genes:f:faf2|FAF2]]|0.484|
|[[:human genes:u:ube2j1|UBE2J1]]|0.462|
|[[:human genes:p:plaa|PLAA]]|0.424|
|[[:human genes:d:dnajc3|DNAJC3]]|0.423|
|[[:human genes:h:hars|HARS]]|0.413|
|[[:human genes:d:dnajb11|DNAJB11]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1826
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AUP1 Expression in NALM6 Cells: 7.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>