======= AVPR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: AVPR2
  * **<color #00a2e8>Official Name</color>**: arginine vasopressin receptor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=554|554]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30518|P30518]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=AVPR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20AVPR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300538|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. {ECO:0000269|PubMed:19440390}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|7TM GPCR Srsx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of renal sodium excretion|
|regulation of systemic arterial blood pressure by vasopressin|
|negative regulation of urine volume|
|vasopressin receptor activity|
|positive regulation of systemic arterial blood pressure|
|interferon-gamma production|
|regulation of renal sodium excretion|
|regulation of urine volume|
|regulation of excretion|
|positive regulation of vasoconstriction|
|regulation of renal system process|
|renal water homeostasis|
|regulation of systemic arterial blood pressure by hormone|
|positive regulation of blood pressure|
|activation of adenylate cyclase activity|
|excretion|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|endocrine process|
|clathrin-coated vesicle membrane|
|regulation of vasoconstriction|
|multicellular organismal water homeostasis|
|I-kappaB kinase/NF-kappaB signaling|
|positive regulation of blood circulation|
|water homeostasis|
|regulation of systemic arterial blood pressure|
|renal system process|
|positive regulation of protein ubiquitination|
|positive regulation of protein modification by small protein conjugation or removal|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|cytokine production|
|vascular process in circulatory system|
|regulation of blood pressure|
|regulation of protein ubiquitination|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of protein modification by small protein conjugation or removal|
|negative regulation of secretion|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|telencephalon development|
|endosome|
|regulation of blood circulation|
|hemostasis|
|multicellular organismal homeostasis|
|forebrain development|
|blood circulation|
|circulatory system process|
|negative regulation of transport|
|regulation of body fluid levels|
|regulation of anatomical structure size|
|regulation of system process|
|cellular response to hormone stimulus|
|brain development|
|head development|
|regulation of secretion|
|membrane organization|
|response to hormone|
|positive regulation of cell population proliferation|
|central nervous system development|
|Golgi apparatus|
|endoplasmic reticulum|
|response to cytokine|
|chemical homeostasis|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|response to endogenous stimulus|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|homeostatic process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of protein modification process|
|regulation of transport|
|system process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17247
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='AVPR2 Expression in NALM6 Cells: 1.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>