======= B3GNT5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: B3GNT5
  * **<color #00a2e8>Official Name</color>**: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84002|84002]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BYG0|Q9BYG0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=B3GNT5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20B3GNT5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615333|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Galactosyl T|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|
|lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity|
|N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity|
|poly-N-acetyllactosamine biosynthetic process|
|poly-N-acetyllactosamine metabolic process|
|galactosyltransferase activity|
|acetylgalactosaminyltransferase activity|
|cellular polysaccharide biosynthetic process|
|polysaccharide biosynthetic process|
|cellular carbohydrate biosynthetic process|
|O-glycan processing|
|glycolipid biosynthetic process|
|cellular polysaccharide metabolic process|
|polysaccharide metabolic process|
|aminoglycan biosynthetic process|
|glycolipid metabolic process|
|liposaccharide metabolic process|
|protein O-linked glycosylation|
|carbohydrate biosynthetic process|
|membrane lipid biosynthetic process|
|aminoglycan metabolic process|
|cellular carbohydrate metabolic process|
|membrane lipid metabolic process|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|carbohydrate metabolic process|
|lipid biosynthetic process|
|Golgi membrane|
|carbohydrate derivative biosynthetic process|
|brain development|
|head development|
|cellular lipid metabolic process|
|central nervous system development|
|Golgi apparatus|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11940
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='B3GNT5 Expression in NALM6 Cells: 1.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>