======= B4GALNT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: B4GALNT2
  * **<color #00a2e8>Official Name</color>**: beta-1,4-N-acetyl-galactosaminyltransferase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=124872|124872]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NHY0|Q8NHY0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=B4GALNT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20B4GALNT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/111730|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the synthesis of the Sd(a) antigen (Sia- alpha2,3-[GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocytes, the colonic mucosa and other tissues. Transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain. {ECO:0000269|PubMed:12678917, ECO:0000269|PubMed:14688233}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glycos transf 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|UDP-N-acetylgalactosamine metabolic process|
|lipid glycosylation|
|UDP-N-acetylglucosamine metabolic process|
|acetylgalactosaminyltransferase activity|
|protein N-linked glycosylation via asparagine|
|peptidyl-asparagine modification|
|nucleotide-sugar metabolic process|
|amino sugar metabolic process|
|integral component of Golgi membrane|
|protein N-linked glycosylation|
|negative regulation of cell-cell adhesion|
|lipid modification|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|negative regulation of cell adhesion|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|regulation of cell-cell adhesion|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|Golgi membrane|
|regulation of cell adhesion|
|peptidyl-amino acid modification|
|cellular lipid metabolic process|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.422|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9921
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='B4GALNT2 Expression in NALM6 Cells: 4.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>