======= BAK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BAK1
  * **<color #00a2e8>Official Name</color>**: BCL2 antagonist/killer 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=578|578]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16611|Q16611]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BAK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BAK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600516|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the mitochondrial apoptosic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases. {ECO:0000269|PubMed:17157251, ECO:0000269|PubMed:8521816}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Bcl-2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|BAK complex|
|B cell negative selection|
|B cell selection|
|post-embryonic camera-type eye morphogenesis|
|fibroblast apoptotic process|
|BH domain binding|
|apoptotic process involved in blood vessel morphogenesis|
|thymocyte apoptotic process|
|post-embryonic eye morphogenesis|
|positive regulation of IRE1-mediated unfolded protein response|
|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|
|response to mycotoxin|
|post-embryonic camera-type eye development|
|post-embryonic animal organ morphogenesis|
|B cell apoptotic process|
|negative regulation of endoplasmic reticulum calcium ion concentration|
|regulation of protein heterodimerization activity|
|vagina development|
|post-embryonic animal morphogenesis|
|regulation of IRE1-mediated unfolded protein response|
|pore complex|
|positive regulation of endoplasmic reticulum unfolded protein response|
|establishment or maintenance of transmembrane electrochemical gradient|
|T cell apoptotic process|
|activation of cysteine-type endopeptidase activity|
|post-embryonic animal organ development|
|apoptotic process involved in morphogenesis|
|response to UV-C|
|mitochondrial fusion|
|female genitalia development|
|lymphocyte apoptotic process|
|integral component of mitochondrial outer membrane|
|endoplasmic reticulum calcium ion homeostasis|
|regulation of protein homodimerization activity|
|release of cytochrome c from mitochondria|
|leukocyte apoptotic process|
|B cell homeostasis|
|regulation of endoplasmic reticulum unfolded protein response|
|negative regulation of peptidyl-serine phosphorylation|
|apoptotic process involved in development|
|positive regulation of release of cytochrome c from mitochondria|
|extrinsic apoptotic signaling pathway in absence of ligand|
|signal transduction in absence of ligand|
|blood vessel remodeling|
|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|
|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|positive regulation of response to endoplasmic reticulum stress|
|endocrine pancreas development|
|zymogen activation|
|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|genitalia development|
|regulation of release of cytochrome c from mitochondria|
|response to fungus|
|lymphocyte homeostasis|
|positive regulation of calcium ion transport into cytosol|
|response to gamma radiation|
|heat shock protein binding|
|apoptotic mitochondrial changes|
|leukocyte homeostasis|
|regulation of mitochondrial membrane potential|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|regulation of mitochondrial membrane permeability|
|pancreas development|
|animal organ regeneration|
|cellular response to mechanical stimulus|
|regulation of membrane permeability|
|regulation of response to endoplasmic reticulum stress|
|cellular response to UV|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|post-embryonic development|
|organelle fusion|
|extrinsic apoptotic signaling pathway|
|regulation of calcium ion transport into cytosol|
|tissue remodeling|
|chaperone binding|
|female sex differentiation|
|myeloid cell homeostasis|
|B cell differentiation|
|camera-type eye morphogenesis|
|cellular response to light stimulus|
|positive regulation of mitochondrion organization|
|response to hydrogen peroxide|
|positive regulation of calcium ion transport|
|endocrine system development|
|ion channel binding|
|response to ethanol|
|cellular response to unfolded protein|
|mitochondrial membrane organization|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of peptidyl-serine phosphorylation|
|response to UV|
|eye morphogenesis|
|intrinsic apoptotic signaling pathway|
|response to ionizing radiation|
|cellular response to topologically incorrect protein|
|appendage morphogenesis|
|limb morphogenesis|
|positive regulation of cysteine-type endopeptidase activity|
|B cell activation|
|regeneration|
|protein processing|
|response to unfolded protein|
|mitochondrial outer membrane|
|positive regulation of endopeptidase activity|
|cellular response to radiation|
|positive regulation of apoptotic signaling pathway|
|regulation of mitochondrion organization|
|appendage development|
|limb development|
|response to topologically incorrect protein|
|positive regulation of peptidase activity|
|response to reactive oxygen species|
|homeostasis of number of cells|
|response to mechanical stimulus|
|mitochondrial transport|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of protein binding|
|protein maturation|
|response to alcohol|
|lymphocyte differentiation|
|regulation of cysteine-type endopeptidase activity|
|regulation of calcium ion transport|
|sensory organ morphogenesis|
|response to endoplasmic reticulum stress|
|sex differentiation|
|positive regulation of ion transport|
|aging|
|positive regulation of cytosolic calcium ion concentration|
|apoptotic signaling pathway|
|response to antibiotic|
|response to light stimulus|
|camera-type eye development|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|regulation of cytosolic calcium ion concentration|
|leukocyte differentiation|
|cellular response to external stimulus|
|positive regulation of proteolysis|
|eye development|
|visual system development|
|sensory system development|
|regulation of binding|
|lymphocyte activation|
|regulation of metal ion transport|
|response to oxidative stress|
|regulation of apoptotic signaling pathway|
|negative regulation of protein phosphorylation|
|blood vessel morphogenesis|
|regulation of endopeptidase activity|
|reproductive structure development|
|reproductive system development|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|response to radiation|
|mitochondrion organization|
|regulation of peptidase activity|
|negative regulation of phosphorylation|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|blood vessel development|
|protein heterodimerization activity|
|divalent inorganic cation homeostasis|
|response to toxic substance|
|vasculature development|
|cardiovascular system development|
|response to inorganic substance|
|sensory organ development|
|cell population proliferation|
|hemopoiesis|
|cellular metal ion homeostasis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|hematopoietic or lymphoid organ development|
|positive regulation of organelle organization|
|metal ion homeostasis|
|cellular cation homeostasis|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|immune system development|
|tube morphogenesis|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|positive regulation of cell death|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of proteolysis|
|regulation of cellular response to stress|
|brain development|
|cellular chemical homeostasis|
|molecular function|
|positive regulation of hydrolase activity|
|cellular response to DNA damage stimulus|
|head development|
|ion homeostasis|
|tube development|
|membrane organization|
|circulatory system development|
|protein homodimerization activity|
|cellular homeostasis|
|regulation of cellular localization|
|response to organic cyclic compound|
|apoptotic process|
|leukocyte activation|
|ion transmembrane transport|
|animal organ morphogenesis|
|central nervous system development|
|positive regulation of transport|
|endoplasmic reticulum|
|response to drug|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|identical protein binding|
|cell activation|
|cell death|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|mitochondrion|
|proteolysis|
|regulation of hydrolase activity|
|transmembrane transport|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|ion transport|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|regulation of transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.7|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|1.71|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.73|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.78|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.8|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.8|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.82|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.84|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|1.85|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.89|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.93|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.97|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.03|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|2.04|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.04|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.07|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.07|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.12|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.19|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.2|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|2.22|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.24|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|2.28|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|2.29|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|2.3|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|2.31|
|[[:results:exp210|LB-100 2μM R05 exp210]]|2.32|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|2.35|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.36|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.38|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|2.44|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|2.45|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|2.45|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.52|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.54|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.63|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.65|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.66|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.86|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.99|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|3.06|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|3.1|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|3.11|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|3.12|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|3.18|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|3.18|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|3.21|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|3.22|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|3.22|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|3.32|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|3.35|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|3.35|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|3.36|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|3.39|
|[[:results:exp539|42°C R08 exp539]]|3.44|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|3.46|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|3.6|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|3.63|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|3.64|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|3.65|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|3.78|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|3.86|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|3.93|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|3.93|
|[[:results:exp211|AICAR 240μM R05 exp211]]|3.97|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|4.15|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|4.51|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|4.52|
|[[:results:exp134|MS023 2μM R03 exp134]]|4.63|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|4.86|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|5.23|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|5.3|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|5.42|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|5.47|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|5.54|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|5.68|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|5.73|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|5.83|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|5.93|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|5.93|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|5.94|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|5.95|
|[[:results:exp116|AICAR 240μM R03 exp116]]|6.13|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|6.4|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|6.55|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|6.56|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|6.61|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|7.03|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|7.17|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|7.18|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|7.39|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|7.44|
|[[:results:exp135|MS023 7μM R03 exp135]]|7.72|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|7.87|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:march5|MARCH5]]|0.846|
|[[:human genes:v:vdac2|VDAC2]]|0.822|
|[[:human genes:a:apaf1|APAF1]]|0.82|
|[[:human genes:c:casp9|CASP9]]|0.799|
|[[:human genes:u:ubqln1|UBQLN1]]|0.781|
|[[:human genes:p:plaa|PLAA]]|0.759|
|[[:human genes:c:cycs|CYCS]]|0.745|
|[[:human genes:h:hccs|HCCS]]|0.698|
|[[:human genes:f:faf2|FAF2]]|0.691|
|[[:human genes:s:serf2|SERF2]]|0.691|
|[[:human genes:d:dohh|DOHH]]|0.686|
|[[:human genes:d:diablo|DIABLO]]|0.651|
|[[:human genes:s:stau1|STAU1]]|0.603|
|[[:human genes:t:thg1l|THG1L]]|0.589|
|[[:human genes:b:bap1|BAP1]]|0.586|
|[[:human genes:a:atad1|ATAD1]]|0.569|
|[[:human genes:m:mlst8|MLST8]]|0.563|
|[[:human genes:r:romo1|ROMO1]]|0.563|
|[[:human genes:m:metap2|METAP2]]|0.561|
|[[:human genes:m:mfn1|MFN1]]|0.554|
|[[:human genes:h:hspd1|HSPD1]]|0.55|
|[[:human genes:r:rptor|RPTOR]]|0.549|
|[[:human genes:u:uap1|UAP1]]|0.541|
|[[:human genes:e:eny2|ENY2]]|0.539|
|[[:human genes:p:pdpk1|PDPK1]]|0.538|
|[[:human genes:t:triap1|TRIAP1]]|0.535|
|[[:human genes:m:mtor|MTOR]]|0.522|
|[[:human genes:g:gfpt1|GFPT1]]|0.522|
|[[:human genes:g:gmppb|GMPPB]]|0.518|
|[[:human genes:v:vhl|VHL]]|0.512|
|[[:human genes:f:fech|FECH]]|0.511|
|[[:human genes:g:gabpa|GABPA]]|0.509|
|[[:human genes:n:nsd1|NSD1]]|0.508|
|[[:human genes:c:crls1|CRLS1]]|0.505|
|[[:human genes:s:srp14|SRP14]]|0.503|
|[[:human genes:k:kctd5|KCTD5]]|0.499|
|[[:human genes:k:kdsr|KDSR]]|0.494|
|[[:human genes:p:ppa2|PPA2]]|0.492|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.489|
|[[:human genes:w:wdr24|WDR24]]|0.488|
|[[:human genes:t:trim28|TRIM28]]|0.482|
|[[:human genes:d:ddhd2|DDHD2]]|0.482|
|[[:human genes:z:zzz3|ZZZ3]]|0.479|
|[[:human genes:f:fbxo11|FBXO11]]|0.478|
|[[:human genes:r:rad23b|RAD23B]]|0.477|
|[[:human genes:o:opa1|OPA1]]|0.472|
|[[:human genes:h:hars|HARS]]|0.471|
|[[:human genes:t:tamm41|TAMM41]]|0.469|
|[[:human genes:r:rnmt|RNMT]]|0.468|
|[[:human genes:b:bcl2l11|BCL2L11]]|0.46|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.46|
|[[:human genes:s:srrd|SRRD]]|0.46|
|[[:human genes:a:atp5j|ATP5J]]|0.459|
|[[:human genes:p:pmm2|PMM2]]|0.458|
|[[:human genes:d:dr1|DR1]]|0.458|
|[[:human genes:u:ube2g2|UBE2G2]]|0.457|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.457|
|[[:human genes:a:alas1|ALAS1]]|0.456|
|[[:human genes:n:nae1|NAE1]]|0.452|
|[[:human genes:e:eif3f|EIF3F]]|0.451|
|[[:human genes:t:taz|TAZ]]|0.45|
|[[:human genes:a:alg1|ALG1]]|0.447|
|[[:human genes:c:cept1|CEPT1]]|0.446|
|[[:human genes:w:wdr59|WDR59]]|0.445|
|[[:human genes:g:gnas|GNAS]]|0.443|
|[[:human genes:u:ube2m|UBE2M]]|0.443|
|[[:human genes:a:atp2a2|ATP2A2]]|0.443|
|[[:human genes:c:csnk2b|CSNK2B]]|0.442|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.441|
|[[:human genes:d:dhps|DHPS]]|0.438|
|[[:human genes:b:bptf|BPTF]]|0.438|
|[[:human genes:u:uba3|UBA3]]|0.435|
|[[:human genes:p:ppp6c|PPP6C]]|0.435|
|[[:human genes:a:atxn10|ATXN10]]|0.434|
|[[:human genes:e:elf2|ELF2]]|0.432|
|[[:human genes:s:slc25a26|SLC25A26]]|0.431|
|[[:human genes:p:pmaip1|PMAIP1]]|0.431|
|[[:human genes:e:exoc4|EXOC4]]|0.426|
|[[:human genes:d:ddx42|DDX42]]|0.426|
|[[:human genes:t:timm13|TIMM13]]|0.425|
|[[:human genes:d:dpagt1|DPAGT1]]|0.424|
|[[:human genes:r:rtcb|RTCB]]|0.424|
|[[:human genes:c:cbfb|CBFB]]|0.423|
|[[:human genes:p:ppcs|PPCS]]|0.422|
|[[:human genes:s:ssb|SSB]]|0.421|
|[[:human genes:a:atp5a1|ATP5A1]]|0.42|
|[[:human genes:n:n6amt1|N6AMT1]]|0.42|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.417|
|[[:human genes:p:pcbp1|PCBP1]]|0.417|
|[[:human genes:s:sec61g|SEC61G]]|0.416|
|[[:human genes:m:meaf6|MEAF6]]|0.416|
|[[:human genes:r:rictor|RICTOR]]|0.415|
|[[:human genes:m:mios|MIOS]]|0.415|
|[[:human genes:g:gemin7|GEMIN7]]|0.414|
|[[:human genes:c:cd81|CD81]]|0.413|
|[[:human genes:r:rpe|RPE]]|0.411|
|[[:human genes:t:tp53|TP53]]|0.41|
|[[:human genes:p:pisd|PISD]]|0.41|
|[[:human genes:n:nudc|NUDC]]|0.409|
|[[:human genes:a:atp5b|ATP5B]]|0.409|
|[[:human genes:a:adsl|ADSL]]|0.407|
|[[:human genes:a:atic|ATIC]]|0.407|
|[[:human genes:g:gtf3a|GTF3A]]|0.403|
|[[:human genes:b:brwd1|BRWD1]]|0.403|
|[[:human genes:r:rnf214|RNF214]]|0.402|
|[[:human genes:r:rpn1|RPN1]]|0.402|
|[[:human genes:i:id3|ID3]]|0.401|
|[[:human genes:a:alg2|ALG2]]|0.401|
|[[:human genes:u:ube2k|UBE2K]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16008
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BAK1 Expression in NALM6 Cells: 4.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>