======= BCAT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BCAT2
  * **<color #00a2e8>Official Name</color>**: branched chain amino acid transaminase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=587|587]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15382|O15382]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BCAT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BCAT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/113530|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a branched chain aminotransferase found in mitochondria. The encoded protein forms a dimer that catalyzes the first step in the production of the branched chain amino acids leucine, isoleucine, and valine. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aminotran 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|leucine biosynthetic process|
|isoleucine metabolic process|
|branched-chain amino acid biosynthetic process|
|isoleucine catabolic process|
|valine biosynthetic process|
|L-valine transaminase activity|
|L-isoleucine transaminase activity|
|L-leucine transaminase activity|
|branched-chain-amino-acid transaminase activity|
|valine metabolic process|
|leucine metabolic process|
|branched-chain amino acid metabolic process|
|branched-chain amino acid catabolic process|
|alpha-amino acid biosynthetic process|
|cellular amino acid biosynthetic process|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|alpha-amino acid catabolic process|
|cellular amino acid catabolic process|
|alpha-amino acid metabolic process|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|mitochondrial matrix|
|small molecule catabolic process|
|regulation of hormone levels|
|small molecule biosynthetic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|response to cytokine|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11976
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BCAT2 Expression in NALM6 Cells: 5.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>