======= BCL3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BCL3
  * **<color #00a2e8>Official Name</color>**: BCL3 transcription coactivator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=602|602]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20749|P20749]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BCL3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BCL3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/109560|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity). {ECO:0000250, ECO:0000269|PubMed:8453667}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank 2|
|Ank|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Bcl3-Bcl10 complex|
|Bcl3/NF-kappaB2 complex|
|follicular dendritic cell differentiation|
|T-helper 2 cell differentiation|
|follicular dendritic cell activation|
|negative regulation of interleukin-8 biosynthetic process|
|positive regulation of interleukin-10 biosynthetic process|
|regulation of interleukin-10 biosynthetic process|
|negative regulation of tumor necrosis factor biosynthetic process|
|type 2 immune response|
|germinal center formation|
|marginal zone B cell differentiation|
|regulation of interleukin-8 biosynthetic process|
|response to UV-C|
|negative regulation of interleukin-8 production|
|mature B cell differentiation involved in immune response|
|T-helper 1 type immune response|
|negative regulation of receptor signaling pathway via JAK-STAT|
|negative regulation of receptor signaling pathway via STAT|
|maintenance of protein location in nucleus|
|defense response to protozoan|
|mature B cell differentiation|
|response to protozoan|
|CD4-positive, alpha-beta T cell differentiation involved in immune response|
|T-helper cell differentiation|
|alpha-beta T cell activation involved in immune response|
|alpha-beta T cell differentiation involved in immune response|
|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|regulation of tumor necrosis factor biosynthetic process|
|negative regulation of cytokine biosynthetic process|
|T cell differentiation involved in immune response|
|spleen development|
|CD4-positive, alpha-beta T cell differentiation|
|positive regulation of interleukin-10 production|
|maintenance of protein localization in organelle|
|CD4-positive, alpha-beta T cell activation|
|B cell activation involved in immune response|
|intrinsic apoptotic signaling pathway by p53 class mediator|
|alpha-beta T cell differentiation|
|regulation of interleukin-10 production|
|negative regulation of tumor necrosis factor production|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|alpha-beta T cell activation|
|positive regulation of interferon-gamma production|
|T cell activation involved in immune response|
|positive regulation of cytokine biosynthetic process|
|regulation of interleukin-8 production|
|I-kappaB kinase/NF-kappaB signaling|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|maintenance of protein location in cell|
|DNA damage response, signal transduction by p53 class mediator|
|protein binding, bridging|
|maintenance of location in cell|
|regulation of interferon-gamma production|
|signal transduction in response to DNA damage|
|regulation of cytokine biosynthetic process|
|maintenance of protein location|
|B cell differentiation|
|regulation of NIK/NF-kappaB signaling|
|lymphocyte activation involved in immune response|
|antimicrobial humoral response|
|signal transduction by p53 class mediator|
|positive regulation of translation|
|regulation of DNA binding|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of receptor signaling pathway via STAT|
|T cell differentiation|
|response to UV|
|intrinsic apoptotic signaling pathway|
|regulation of tumor necrosis factor production|
|positive regulation of cellular amide metabolic process|
|regulation of tumor necrosis factor superfamily cytokine production|
|B cell activation|
|midbody|
|protein localization to nucleus|
|maintenance of location|
|humoral immune response mediated by circulating immunoglobulin|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|T cell activation|
|lymphocyte differentiation|
|lymphocyte mediated immunity|
|negative regulation of cytokine production|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|response to virus|
|apoptotic signaling pathway|
|response to light stimulus|
|defense response to bacterium|
|leukocyte differentiation|
|transcription factor binding|
|extracellular matrix organization|
|humoral immune response|
|regulation of translation|
|regulation of binding|
|lymphocyte activation|
|extracellular structure organization|
|regulation of cellular amide metabolic process|
|response to radiation|
|positive regulation of cytokine production|
|posttranscriptional regulation of gene expression|
|hemopoiesis|
|protein-containing complex|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|immune system development|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|intracellular membrane-bounded organelle|
|response to bacterium|
|regulation of cytokine production|
|perinuclear region of cytoplasm|
|protein localization to organelle|
|leukocyte mediated immunity|
|cellular response to DNA damage stimulus|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|apoptotic process|
|leukocyte activation|
|defense response to other organism|
|negative regulation of cell death|
|programmed cell death|
|cell activation|
|immune effector process|
|cell death|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of intracellular signal transduction|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7630
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BCL3 Expression in NALM6 Cells: -0.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>