======= BCO2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BCO2
  * **<color #00a2e8>Official Name</color>**: beta-carotene oxygenase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83875|83875]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BYV7|Q9BYV7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BCO2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BCO2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611740|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of beta-apo-10'-carotenal and beta-ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects. {ECO:0000269|PubMed:21106934}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RPE65|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|beta,beta-carotene-9,10-cleaving oxygenase activity|
|beta-carotene 15,15-monooxygenase activity|
|carotenoid dioxygenase activity|
|xanthophyll metabolic process|
|terpene catabolic process|
|carotene catabolic process|
|carotene metabolic process|
|retinal isomerase activity|
|tetraterpenoid metabolic process|
|carotenoid metabolic process|
|terpene metabolic process|
|isoprenoid catabolic process|
|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|
|retinal metabolic process|
|retinoic acid metabolic process|
|cellular aldehyde metabolic process|
|regulation of mitochondrial membrane potential|
|retinoid metabolic process|
|diterpenoid metabolic process|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|isoprenoid metabolic process|
|regulation of reactive oxygen species metabolic process|
|cellular lipid catabolic process|
|hormone metabolic process|
|lipid catabolic process|
|mitochondrial matrix|
|regulation of membrane potential|
|monocarboxylic acid metabolic process|
|regulation of hormone levels|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|lipid metabolic process|
|mitochondrion|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.73|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-1.7|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.7|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.7|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|1.82|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6957
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BCO2 Expression in NALM6 Cells: 4.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>