======= BECN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BECN1
  * **<color #00a2e8>Official Name</color>**: beclin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8678|8678]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14457|Q14457]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BECN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BECN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604378|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a central role in autophagy (PubMed:23184933, PubMed:28445460). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530, PubMed:26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense. {ECO:0000269|PubMed:20208530, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:23184933, ECO:0000269|PubMed:25275521, ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:28445460, ECO:0000269|PubMed:9765397, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|APG6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of lysosome organization|
|cellular response to aluminum ion|
|positive regulation of attachment of mitotic spindle microtubules to kinetochore|
|regulation of attachment of mitotic spindle microtubules to kinetochore|
|protein localization by the Cvt pathway|
|phosphatidylinositol 3-kinase complex, class III, type I|
|phosphatidylinositol 3-kinase complex, class III, type II|
|regulation of lysosome organization|
|response to aluminum ion|
|response to iron(II) ion|
|positive regulation of attachment of spindle microtubules to kinetochore|
|phosphatidylinositol 3-kinase complex, class III|
|mitophagy|
|regulation of metaphase plate congression|
|positive regulation of autophagosome assembly|
|response to vitamin E|
|regulation of attachment of spindle microtubules to kinetochore|
|engulfment of apoptotic cell|
|cellular response to nitrogen levels|
|negative regulation of autophagosome assembly|
|cellular response to nitrogen starvation|
|positive regulation of vacuole organization|
|late endosome to vacuole transport|
|positive regulation of mitotic sister chromatid segregation|
|response to mitochondrial depolarisation|
|amyloid-beta metabolic process|
|phosphatidylinositol 3-kinase binding|
|early endosome to late endosome transport|
|selective autophagy|
|response to lead ion|
|vesicle-mediated transport between endosomal compartments|
|phagophore assembly site|
|receptor catabolic process|
|positive regulation of chromosome segregation|
|positive regulation of cardiac muscle hypertrophy|
|cellular response to copper ion|
|positive regulation of muscle hypertrophy|
|response to iron ion|
|negative regulation of macroautophagy|
|GTPase binding|
|regulation of autophagosome assembly|
|negative regulation of organelle assembly|
|autophagy of mitochondrion|
|apoptotic cell clearance|
|mitochondrion disassembly|
|regulation of vacuole organization|
|cellular response to glucose starvation|
|cellular response to epidermal growth factor stimulus|
|cellular response to amino acid starvation|
|response to copper ion|
|mitotic metaphase plate congression|
|response to amino acid starvation|
|response to epidermal growth factor|
|positive regulation of mitotic nuclear division|
|cellular defense response|
|negative regulation of reactive oxygen species metabolic process|
|metaphase plate congression|
|regulation of cardiac muscle hypertrophy|
|positive regulation of intrinsic apoptotic signaling pathway|
|regulation of muscle hypertrophy|
|lytic vacuole organization|
|lysosome organization|
|phagocytic vesicle|
|autophagosome assembly|
|protein localization to vacuole|
|organelle disassembly|
|autophagosome organization|
|extrinsic component of membrane|
|positive regulation of nuclear division|
|positive regulation of macroautophagy|
|regulation of mitotic sister chromatid segregation|
|autophagosome|
|cellular response to hydrogen peroxide|
|establishment of chromosome localization|
|chromosome localization|
|positive regulation of organelle assembly|
|regulation of sister chromatid segregation|
|negative regulation of autophagy|
|regulation of muscle adaptation|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|response to vitamin|
|regulation of cytokinesis|
|mitochondrial membrane|
|regulation of chromosome segregation|
|receptor metabolic process|
|mitotic sister chromatid segregation|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of autophagy|
|phagocytosis, engulfment|
|vacuole organization|
|cellular response to reactive oxygen species|
|plasma membrane invagination|
|vacuolar transport|
|sister chromatid segregation|
|membrane invagination|
|cytosolic transport|
|mitotic nuclear division|
|positive regulation of mitotic cell cycle|
|cellular response to starvation|
|regulation of intrinsic apoptotic signaling pathway|
|macroautophagy|
|regulation of mitotic nuclear division|
|regulation of cell division|
|trans-Golgi network|
|regulation of macroautophagy|
|positive regulation of apoptotic signaling pathway|
|positive regulation of chromosome organization|
|regulation of reactive oxygen species metabolic process|
|regulation of nuclear division|
|defense response to virus|
|cellular response to metal ion|
|response to starvation|
|response to reactive oxygen species|
|endosome membrane|
|cellular response to toxic substance|
|response to nutrient|
|nuclear chromosome segregation|
|cellular response to inorganic substance|
|regulation of organelle assembly|
|cellular response to nutrient levels|
|regulation of muscle system process|
|cellular response to oxidative stress|
|negative regulation of cellular catabolic process|
|process utilizing autophagic mechanism|
|autophagy|
|cellular response to extracellular stimulus|
|endosome|
|chromosome segregation|
|aging|
|response to virus|
|protein deubiquitination|
|nuclear division|
|positive regulation of cell cycle process|
|ubiquitin protein ligase binding|
|protein modification by small protein removal|
|response to antibiotic|
|negative regulation of catabolic process|
|organelle fission|
|phagocytosis|
|regulation of autophagy|
|cellular response to external stimulus|
|response to hypoxia|
|regulation of chromosome organization|
|response to decreased oxygen levels|
|establishment of organelle localization|
|positive regulation of cellular catabolic process|
|response to metal ion|
|negative regulation of organelle organization|
|positive regulation of cell cycle|
|response to oxygen levels|
|response to oxidative stress|
|regulation of apoptotic signaling pathway|
|cellular component disassembly|
|cellular response to drug|
|dendrite|
|positive regulation of catabolic process|
|mitochondrion organization|
|protein kinase binding|
|cell division|
|response to nutrient levels|
|cellular response to growth factor stimulus|
|response to toxic substance|
|positive regulation of cellular component biogenesis|
|peptide metabolic process|
|response to extracellular stimulus|
|response to growth factor|
|response to inorganic substance|
|endocytosis|
|organelle localization|
|regulation of system process|
|mitotic cell cycle process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|negative regulation of cell population proliferation|
|import into cell|
|mitotic cell cycle|
|positive regulation of cell death|
|viral process|
|negative regulation of cellular component organization|
|protein localization to organelle|
|regulation of cell cycle process|
|organelle assembly|
|symbiotic process|
|cellular amide metabolic process|
|neuron development|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|membrane organization|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|response to organic cyclic compound|
|apoptotic process|
|endoplasmic reticulum membrane|
|defense response to other organism|
|regulation of cellular component biogenesis|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|regulation of catabolic process|
|cell cycle process|
|neuron differentiation|
|endoplasmic reticulum|
|response to drug|
|positive regulation of intracellular signal transduction|
|macromolecule catabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|chromosome organization|
|cell death|
|immune effector process|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|mitochondrion|
|proteolysis|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|cell cycle|
|response to endogenous stimulus|
|intracellular transport|
|generation of neurons|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.5|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.78|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.76|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.74|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.7|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.79|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.94|
|[[:results:exp131|L-74142 5μM R03 exp131]]|2.39|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1836
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BECN1 Expression in NALM6 Cells: 5.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>