======= BHLHB9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BHLHB9
  * **<color #00a2e8>Official Name</color>**: basic helix-loop-helix family member b9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80823|80823]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6PI77|Q6PI77]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BHLHB9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BHLHB9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of a gene family which encodes proteins with a basic helix-loop-helix domain. Other members of this gene family encode proteins which function as transcription factors, either enhancing or inhibiting transcription depending on the activity of other DNA binding proteins. The coding region of this gene is located entirely within the terminal exon. The encoded protein may be involved in the survival of neurons (PMID: 15034937). Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in the control of cellular aging and survival.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF634|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of dendritic spine morphogenesis|
|positive regulation of dendrite morphogenesis|
|positive regulation of dendritic spine development|
|regulation of dendritic spine morphogenesis|
|positive regulation of synapse assembly|
|positive regulation of dendrite development|
|regulation of dendritic spine development|
|regulation of dendrite morphogenesis|
|regulation of postsynapse organization|
|regulation of synapse assembly|
|negative regulation of neuron apoptotic process|
|regulation of dendrite development|
|positive regulation of cell morphogenesis involved in differentiation|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|learning or memory|
|positive regulation of neuron projection development|
|cognition|
|regulation of cell morphogenesis involved in differentiation|
|regulation of neuron death|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|positive regulation of neurogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|positive regulation of cellular component biogenesis|
|positive regulation of nervous system development|
|positive regulation of cell development|
|behavior|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of neurogenesis|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of nervous system development|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|negative regulation of cell death|
|regulation of anatomical structure morphogenesis|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|nervous system process|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|neurogenesis|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|1.98|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2.11|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|2.55|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.46|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13455
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BHLHB9 Expression in NALM6 Cells: 2.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>