======= BNIP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BNIP1
  * **<color #00a2e8>Official Name</color>**: BCL2 interacting protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=662|662]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12981|Q12981]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BNIP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BNIP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603291|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sec20|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endoplasmic reticulum membrane fusion|
|SNAP receptor activity|
|SNARE complex|
|execution phase of apoptosis|
|endoplasmic reticulum organization|
|organelle membrane fusion|
|retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|
|organelle fusion|
|mitochondrial membrane|
|integral component of endoplasmic reticulum membrane|
|membrane fusion|
|nuclear envelope|
|Golgi vesicle transport|
|endomembrane system organization|
|intracellular membrane-bounded organelle|
|membrane organization|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|endoplasmic reticulum membrane|
|negative regulation of cell death|
|endoplasmic reticulum|
|programmed cell death|
|cell death|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.59|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.35|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-2.28|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-2.26|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.97|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-1.88|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.81|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-1.8|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-1.78|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5169
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BNIP1 Expression in NALM6 Cells: 3.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>