======= BRF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BRF1
  * **<color #00a2e8>Official Name</color>**: BRF1 RNA polymerase III transcription initiation factor subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2972|2972]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92994|Q92994]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BRF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BRF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604902|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Several alternatively spliced variants encoding different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. [provided by RefSeq, Jun 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BRF1|
|TFIIB|
|TF Zn Ribbon|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase III type 3 promoter sequence-specific DNA binding|
|transcription factor TFIIIB complex|
|RNA polymerase III preinitiation complex assembly|
|tRNA transcription|
|positive regulation of transcription by RNA polymerase III|
|transcription initiation from RNA polymerase III promoter|
|rRNA transcription|
|TBP-class protein binding|
|regulation of transcription by RNA polymerase III|
|transcription preinitiation complex assembly|
|transcription by RNA polymerase III|
|ncRNA transcription|
|protein-DNA complex assembly|
|DNA-templated transcription, initiation|
|protein-DNA complex subunit organization|
|transcription factor binding|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|cellular protein-containing complex assembly|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.71|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 377/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|13/28|
|blood|18/28|
|bone|12/25|
|breast|14/33|
|central nervous system|28/56|
|cervix|1/4|
|colorectal|11/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|9/15|
|kidney|15/21|
|liver|11/20|
|lung|32/75|
|lymphocyte|9/14|
|ovary|13/26|
|pancreas|9/24|
|peripheral nervous system|7/16|
|plasma cell|11/15|
|prostate|0/1|
|skin|14/24|
|soft tissue|3/7|
|thyroid|1/2|
|upper aerodigestive|9/22|
|urinary tract|17/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2308
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BRF1 Expression in NALM6 Cells: 6.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>