======= BRSK2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BRSK2
  * **<color #00a2e8>Official Name</color>**: BR serine/threonine kinase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9024|9024]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IWQ3|Q8IWQ3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BRSK2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BRSK2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609236|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:22669945, ECO:0000269|PubMed:22798068, ECO:0000269|PubMed:23029325}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ATPase regulator activity|
|microtubule cytoskeleton organization involved in establishment of planar polarity|
|distal axon|
|regulation of synaptic vesicle clustering|
|regulation of retrograde protein transport, ER to cytosol|
|tau-protein kinase activity|
|establishment of planar polarity|
|establishment of tissue polarity|
|regulation of protein exit from endoplasmic reticulum|
|regulation of ERAD pathway|
|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|
|morphogenesis of a polarized epithelium|
|tau protein binding|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|actin cytoskeleton reorganization|
|ATPase binding|
|regulation of ATPase activity|
|regulation of response to endoplasmic reticulum stress|
|ERAD pathway|
|regulation of synaptic vesicle cycle|
|establishment of cell polarity|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|intrinsic apoptotic signaling pathway|
|peptidyl-serine phosphorylation|
|regulation of insulin secretion|
|regulation of proteasomal protein catabolic process|
|regulation of axonogenesis|
|establishment or maintenance of cell polarity|
|peptidyl-serine modification|
|regulation of peptide hormone secretion|
|magnesium ion binding|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of intracellular protein transport|
|regulation of cellular protein catabolic process|
|response to endoplasmic reticulum stress|
|regulation of hormone secretion|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|apoptotic signaling pathway|
|regulation of cell morphogenesis involved in differentiation|
|proteasomal protein catabolic process|
|regulation of intracellular transport|
|protein serine/threonine kinase activity|
|axonogenesis|
|regulation of protein catabolic process|
|axon development|
|morphogenesis of an epithelium|
|cell morphogenesis involved in neuron differentiation|
|protein kinase binding|
|regulation of protein secretion|
|microtubule cytoskeleton organization|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|centrosome|
|cell division|
|regulation of peptide secretion|
|actin cytoskeleton organization|
|regulation of neuron projection development|
|cell part morphogenesis|
|regulation of hormone levels|
|regulation of cellular protein localization|
|regulation of vesicle-mediated transport|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|actin filament-based process|
|proteolysis involved in cellular protein catabolic process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|regulation of neuron differentiation|
|neuron projection development|
|microtubule-based process|
|mitotic cell cycle|
|protein catabolic process|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|regulation of protein transport|
|regulation of cell projection organization|
|cell morphogenesis|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|exocytosis|
|regulation of secretion|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|peptidyl-amino acid modification|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|protein phosphorylation|
|regulation of catabolic process|
|cell cycle process|
|response to organonitrogen compound|
|secretion by cell|
|neuron differentiation|
|endoplasmic reticulum|
|regulation of protein localization|
|export from cell|
|macromolecule catabolic process|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|cell death|
|cytoskeleton organization|
|epithelium development|
|secretion|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|proteolysis|
|regulation of hydrolase activity|
|phosphorylation|
|cell cycle|
|regulation of response to stress|
|ATP binding|
|generation of neurons|
|neurogenesis|
|cell development|
|intracellular signal transduction|
|cellular response to stress|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8689
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BRSK2 Expression in NALM6 Cells: -2.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>