======= BRWD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BRWD1
  * **<color #00a2e8>Official Name</color>**: bromodomain and WD repeat domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54014|54014]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NSI6|Q9NSI6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BRWD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BRWD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617824|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
|Bromodomain|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-7-mediated signaling pathway|
|cellular response to interleukin-7|
|response to interleukin-7|
|regulation of cell shape|
|regulation of cell morphogenesis|
|cytokine-mediated signaling pathway|
|chromatin organization|
|molecular function|
|nucleolus|
|cellular response to cytokine stimulus|
|regulation of anatomical structure morphogenesis|
|chromosome organization|
|response to cytokine|
|cytoskeleton organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp124|GSK343 3μM R03 exp124]]|-2.02|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-1.75|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.71|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.83|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.88|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.89|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.9|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.98|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.99|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.05|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.09|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.1|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.15|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.2|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.38|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.49|
|[[:human genes:c:cycs|CYCS]]|0.475|
|[[:human genes:t:triap1|TRIAP1]]|0.473|
|[[:human genes:h:hccs|HCCS]]|0.471|
|[[:human genes:o:opa1|OPA1]]|0.468|
|[[:human genes:p:pmm2|PMM2]]|0.436|
|[[:human genes:a:apaf1|APAF1]]|0.427|
|[[:human genes:c:crls1|CRLS1]]|0.426|
|[[:human genes:d:dohh|DOHH]]|0.426|
|[[:human genes:m:mrpl23|MRPL23]]|0.42|
|[[:human genes:t:tamm41|TAMM41]]|0.42|
|[[:human genes:s:slc25a26|SLC25A26]]|0.418|
|[[:human genes:p:plaa|PLAA]]|0.417|
|[[:human genes:t:timm13|TIMM13]]|0.416|
|[[:human genes:p:ppp6c|PPP6C]]|0.414|
|[[:human genes:r:romo1|ROMO1]]|0.409|
|[[:human genes:r:rpe|RPE]]|0.407|
|[[:human genes:f:faf2|FAF2]]|0.406|
|[[:human genes:m:mfn1|MFN1]]|0.404|
|[[:human genes:u:uap1|UAP1]]|0.404|
|[[:human genes:b:bak1|BAK1]]|0.403|
|[[:human genes:m:mrps14|MRPS14]]|0.401|
|[[:human genes:f:fastkd5|FASTKD5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9869
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BRWD1 Expression in NALM6 Cells: 7.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>