======= C18orf8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RMC1
  * **<color #00a2e8>Official Name</color>**: regulator of MON1-CCZ1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29919|29919]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96DM3|Q96DM3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C18orf8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C18orf8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620267|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a colon cancer associated protein. [provided by RefSeq, Jan 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Componement of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization (PubMed:29038162). {ECO:0000269|PubMed:29038162}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mic1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Mon1-Ccz1 complex|
|late endosome membrane|
|autophagy|
|process utilizing autophagic mechanism|
|lysosomal membrane|
|regulation of autophagy|
|regulation of cellular catabolic process|
|regulation of catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.91|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.36|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-2.24|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.21|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.06|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-1.87|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.77|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.76|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-1.73|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.71|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|1.74|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|1.77|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|1.88|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.09|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|2.09|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|2.15|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2.65|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:ccz1|CCZ1]]|0.431|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14707
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C18ORF8 Expression in NALM6 Cells: 4.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>