======= C1QTNF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: C1QTNF1
  * **<color #00a2e8>Official Name</color>**: C1q and TNF related 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=114897|114897]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BXJ1|Q9BXJ1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C1QTNF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C1QTNF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610365|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Collagen|
|C1q|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of mineralocorticoid secretion|
|positive regulation of aldosterone secretion|
|regulation of aldosterone secretion|
|regulation of mineralocorticoid secretion|
|positive regulation of corticosteroid hormone secretion|
|positive regulation of steroid hormone secretion|
|negative regulation of platelet aggregation|
|protein heterotrimerization|
|negative regulation of homotypic cell-cell adhesion|
|regulation of corticosteroid hormone secretion|
|regulation of platelet aggregation|
|regulation of steroid hormone secretion|
|negative regulation of platelet activation|
|regulation of homotypic cell-cell adhesion|
|regulation of platelet activation|
|regulation of endocrine process|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|negative regulation of coagulation|
|protein trimerization|
|positive regulation of lipid transport|
|collagen trimer|
|collagen binding|
|negative regulation of wound healing|
|regulation of blood coagulation|
|regulation of hemostasis|
|positive regulation of lipid localization|
|regulation of coagulation|
|negative regulation of response to wounding|
|protein heterooligomerization|
|regulation of lipid transport|
|regulation of glucose metabolic process|
|positive regulation of hormone secretion|
|regulation of lipid localization|
|regulation of wound healing|
|regulation of cellular carbohydrate metabolic process|
|positive regulation of protein kinase B signaling|
|regulation of response to wounding|
|negative regulation of cell-cell adhesion|
|negative regulation of cell activation|
|regulation of carbohydrate metabolic process|
|regulation of protein kinase B signaling|
|regulation of hormone secretion|
|negative regulation of cell adhesion|
|positive regulation of cytosolic calcium ion concentration|
|regulation of cytosolic calcium ion concentration|
|protein homooligomerization|
|negative regulation of response to external stimulus|
|regulation of cell-cell adhesion|
|positive regulation of secretion by cell|
|regulation of small molecule metabolic process|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|regulation of body fluid levels|
|protein complex oligomerization|
|regulation of hormone levels|
|positive regulation of MAPK cascade|
|cellular metal ion homeostasis|
|regulation of system process|
|metal ion homeostasis|
|cellular cation homeostasis|
|regulation of cell activation|
|cellular ion homeostasis|
|regulation of cell adhesion|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|ion homeostasis|
|regulation of secretion|
|cellular homeostasis|
|positive regulation of transport|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|regulation of response to stress|
|protein-containing complex assembly|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp144|PFI-3 10μM R03 exp144]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7907
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C1QTNF1 Expression in NALM6 Cells: -0.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>