======= C21orf59 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CFAP298
  * **<color #00a2e8>Official Name</color>**: cilia and flagella associated protein 298
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56683|56683]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P57076|P57076]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C21orf59&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C21orf59|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615494|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that plays a critical role in dynein arm assembly and motile cilia function. Mutations in this gene result in primary ciliary dyskinesia. Naturally occuring readthrough transcription occurs from this locus to the downstream t-complex 10 like (TCP10L) gene. [provided by RefSeq, Apr 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly (PubMed:24094744). Seems to be important for initiation rather than maintenance of cilium motility (By similarity). Required for correct positioning of the cilium at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway (By similarity). May suppress canonical Wnt signaling activity (By similarity). {ECO:0000250|UniProtKB:Q6DRC3, ECO:0000269|PubMed:24094744}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF2870|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of cilium movement|
|regulation of microtubule-based movement|
|cilium|
|regulation of microtubule-based process|
|cilium assembly|
|cytoskeleton|
|cilium organization|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|organelle assembly|
|regulation of cellular component movement|
|plasma membrane bounded cell projection organization|
|cell projection organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-2.08|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-1.91|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.84|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-1.78|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-1.76|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.75|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.97|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.441|
|[[:human genes:r:rptor|RPTOR]]|0.432|
|[[:human genes:a:adsl|ADSL]]|0.428|
|[[:human genes:g:gmppb|GMPPB]]|0.426|
|[[:human genes:g:gnb1l|GNB1L]]|0.422|
|[[:human genes:e:exoc4|EXOC4]]|0.422|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.415|
|[[:human genes:d:dohh|DOHH]]|0.415|
|[[:human genes:w:wdr82|WDR82]]|0.414|
|[[:human genes:o:osgep|OSGEP]]|0.406|
|[[:human genes:c:ccdc101|CCDC101]]|0.404|
|[[:human genes:r:rnmt|RNMT]]|0.401|
|[[:human genes:q:qars|QARS]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 726/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/26|
|breast|33/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 375
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C21ORF59 Expression in NALM6 Cells: 5.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>