======= C21orf91 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: C21orf91
  * **<color #00a2e8>Official Name</color>**: chromosome 21 open reading frame 91
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54149|54149]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NYK6|Q9NYK6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C21orf91&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C21orf91|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in cortical progenitor cell proliferation and differentiation. Promotes dendritic spine development of post- migratory cortical projection neurons by modulating the beta- catenin signaling pathway. {ECO:0000250|UniProtKB:Q9D7G4}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EURL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.21|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-1.97|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.9|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.75|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-1.71|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|2.02|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.02|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.21|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.21|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|2.25|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.67|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|3.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12714
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C21orf91 Expression in NALM6 Cells: 9.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>