======= C3AR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: C3AR1
  * **<color #00a2e8>Official Name</color>**: complement C3a receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=719|719]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16581|Q16581]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C3AR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C3AR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605246|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  C3a is an anaphylatoxin released during activation of the complement system. The protein encoded by this gene is an orphan G protein-coupled receptor for C3a. Binding of C3a by the encoded receptor activates chemotaxis, granule enzyme release, superoxide anion production, and bacterial opsonization. [provided by RefSeq, May 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|7TM GPCR Srsx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|complement component C3a receptor activity|
|complement receptor mediated signaling pathway|
|positive regulation of macrophage chemotaxis|
|positive regulation of macrophage migration|
|positive regulation of neutrophil chemotaxis|
|positive regulation of granulocyte chemotaxis|
|regulation of macrophage chemotaxis|
|positive regulation of vascular endothelial growth factor production|
|positive regulation of neutrophil migration|
|regulation of neutrophil chemotaxis|
|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|
|regulation of vascular endothelial growth factor production|
|regulation of neutrophil migration|
|regulation of macrophage migration|
|regulation of granulocyte chemotaxis|
|regulation of mononuclear cell migration|
|azurophil granule membrane|
|positive regulation of leukocyte chemotaxis|
|specific granule membrane|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|regulation of leukocyte chemotaxis|
|regulation of complement activation|
|positive regulation of leukocyte migration|
|positive regulation of chemotaxis|
|regulation of humoral immune response|
|positive regulation of angiogenesis|
|positive regulation of vasculature development|
|regulation of leukocyte migration|
|regulation of chemotaxis|
|positive regulation of cytosolic calcium ion concentration|
|regulation of angiogenesis|
|regulation of vasculature development|
|regulation of cytosolic calcium ion concentration|
|blood circulation|
|circulatory system process|
|cellular calcium ion homeostasis|
|immune response-activating cell surface receptor signaling pathway|
|calcium ion homeostasis|
|positive regulation of cytokine production|
|regulation of immune effector process|
|cellular divalent inorganic cation homeostasis|
|immune response-regulating cell surface receptor signaling pathway|
|neutrophil degranulation|
|divalent inorganic cation homeostasis|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|inflammatory response|
|positive regulation of cell migration|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|cellular metal ion homeostasis|
|immune response-activating signal transduction|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|leukocyte activation involved in immune response|
|metal ion homeostasis|
|cell activation involved in immune response|
|activation of immune response|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of cytokine production|
|regulated exocytosis|
|cation homeostasis|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|cellular chemical homeostasis|
|leukocyte mediated immunity|
|ion homeostasis|
|exocytosis|
|regulation of cell migration|
|positive regulation of immune response|
|cellular homeostasis|
|regulation of cell motility|
|leukocyte activation|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|export from cell|
|regulation of anatomical structure morphogenesis|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|chemical homeostasis|
|secretion|
|positive regulation of immune system process|
|regulation of immune response|
|locomotion|
|G protein-coupled receptor signaling pathway|
|defense response|
|positive regulation of developmental process|
|integral component of plasma membrane|
|homeostatic process|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|immune response|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.74|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-1.7|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5360
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.69 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C3AR1 Expression in NALM6 Cells: -2.69'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>