======= C5AR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: C5AR1
  * **<color #00a2e8>Official Name</color>**: complement C5a receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=728|728]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P21730|P21730]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C5AR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C5AR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/113995|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520). {ECO:0000269|PubMed:10636859, ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:1847994, ECO:0000269|PubMed:7622471, ECO:0000269|PubMed:8182049, ECO:0000269|PubMed:9553099}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|complement component C5a binding|
|complement component C5a receptor activity|
|complement component C5a signaling pathway|
|cell proliferation in hindbrain|
|response to peptidoglycan|
|regulation of tau-protein kinase activity|
|complement receptor mediated signaling pathway|
|positive regulation of macrophage chemotaxis|
|mRNA transcription by RNA polymerase II|
|astrocyte activation|
|positive regulation of macrophage migration|
|amyloid-beta clearance|
|presynapse organization|
|positive regulation of neutrophil chemotaxis|
|mRNA transcription|
|regulation of macrophage chemotaxis|
|positive regulation of granulocyte chemotaxis|
|positive regulation of vascular endothelial growth factor production|
|positive regulation of neutrophil migration|
|regulation of neutrophil chemotaxis|
|microglial cell activation|
|leukocyte activation involved in inflammatory response|
|activation of phospholipase C activity|
|regulation of vascular endothelial growth factor production|
|regulation of neutrophil migration|
|astrocyte development|
|regulation of macrophage migration|
|glial cell activation|
|neuroinflammatory response|
|regulation of granulocyte chemotaxis|
|positive regulation of phospholipase C activity|
|regulation of mononuclear cell migration|
|regulation of phospholipase C activity|
|macrophage activation|
|astrocyte differentiation|
|cellular defense response|
|positive regulation of phospholipase activity|
|apical part of cell|
|regulation of phospholipase activity|
|positive regulation of lipase activity|
|animal organ regeneration|
|neural precursor cell proliferation|
|neutrophil chemotaxis|
|positive regulation of leukocyte chemotaxis|
|granulocyte chemotaxis|
|neutrophil migration|
|defense response to Gram-positive bacterium|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|secretory granule membrane|
|regulation of lipase activity|
|granulocyte migration|
|glial cell development|
|regulation of leukocyte chemotaxis|
|regulation of complement activation|
|myeloid leukocyte migration|
|positive regulation of leukocyte migration|
|positive regulation of chemotaxis|
|regulation of humoral immune response|
|leukocyte chemotaxis|
|negative regulation of neuron apoptotic process|
|hindbrain development|
|activation of MAPK activity|
|regeneration|
|positive regulation of angiogenesis|
|glial cell differentiation|
|positive regulation of vasculature development|
|positive regulation of epithelial cell proliferation|
|regulation of leukocyte migration|
|basolateral plasma membrane|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|cell chemotaxis|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|gliogenesis|
|positive regulation of MAP kinase activity|
|synapse organization|
|positive regulation of cytosolic calcium ion concentration|
|regulation of angiogenesis|
|regulation of ERK1 and ERK2 cascade|
|cognition|
|regulation of neuron death|
|response to lipopolysaccharide|
|regulation of vasculature development|
|response to molecule of bacterial origin|
|regulation of cytosolic calcium ion concentration|
|activation of protein kinase activity|
|defense response to bacterium|
|regulation of epithelial cell proliferation|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|leukocyte migration|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of cytokine production|
|regulation of immune effector process|
|cellular divalent inorganic cation homeostasis|
|transcription by RNA polymerase II|
|immune response-regulating cell surface receptor signaling pathway|
|neutrophil degranulation|
|divalent inorganic cation homeostasis|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|inflammatory response|
|positive regulation of cell migration|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|regulation of protein serine/threonine kinase activity|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|sensory perception of chemical stimulus|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|cell population proliferation|
|cellular metal ion homeostasis|
|immune response-activating signal transduction|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|cell surface|
|leukocyte activation involved in immune response|
|metal ion homeostasis|
|cell activation involved in immune response|
|activation of immune response|
|cellular cation homeostasis|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|cellular ion homeostasis|
|RNA biosynthetic process|
|positive regulation of transferase activity|
|response to bacterium|
|regulation of cytokine production|
|mRNA metabolic process|
|regulated exocytosis|
|cation homeostasis|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|brain development|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|leukocyte mediated immunity|
|positive regulation of hydrolase activity|
|head development|
|ion homeostasis|
|exocytosis|
|regulation of protein kinase activity|
|regulation of cell migration|
|response to lipid|
|positive regulation of immune response|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|apoptotic process|
|leukocyte activation|
|defense response to other organism|
|cell migration|
|sensory perception|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|response to organonitrogen compound|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|export from cell|
|programmed cell death|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|cell death|
|immune effector process|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|chemical homeostasis|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|nervous system process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|RNA metabolic process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|vesicle-mediated transport|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.42|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.76|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.81|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|2.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7775
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.97 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C5AR1 Expression in NALM6 Cells: 1.97'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>