======= C5AR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: C5AR2
  * **<color #00a2e8>Official Name</color>**: complement component 5a receptor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27202|27202]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P296|Q9P296]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C5AR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C5AR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609949|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways. {ECO:0000269|PubMed:11773063, ECO:0000269|PubMed:15833747, ECO:0000269|PubMed:19615750}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of granulocyte chemotaxis|
|complement component C5a receptor activity|
|complement component C5a signaling pathway|
|negative regulation of neutrophil chemotaxis|
|negative regulation of neutrophil migration|
|negative regulation of interleukin-6 secretion|
|complement receptor mediated signaling pathway|
|negative regulation of leukocyte chemotaxis|
|regulation of interleukin-8 secretion|
|regulation of neutrophil chemotaxis|
|basal plasma membrane|
|regulation of neutrophil migration|
|regulation of granulocyte chemotaxis|
|negative regulation of interleukin-6 production|
|negative regulation of leukocyte migration|
|negative regulation of chemotaxis|
|negative regulation of tumor necrosis factor production|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|negative regulation of cytokine secretion|
|regulation of interleukin-8 production|
|apical part of cell|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|regulation of leukocyte chemotaxis|
|regulation of complement activation|
|negative regulation of protein secretion|
|regulation of humoral immune response|
|negative regulation of peptide secretion|
|regulation of interleukin-6 production|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|positive regulation of epithelial cell proliferation|
|regulation of leukocyte migration|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|negative regulation of secretion|
|negative regulation of cell migration|
|negative regulation of cytokine production|
|negative regulation of cell motility|
|positive regulation of cytosolic calcium ion concentration|
|regulation of ERK1 and ERK2 cascade|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|regulation of cytosolic calcium ion concentration|
|regulation of epithelial cell proliferation|
|negative regulation of response to external stimulus|
|cellular calcium ion homeostasis|
|negative regulation of immune system process|
|calcium ion homeostasis|
|immune response-activating cell surface receptor signaling pathway|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|regulation of immune effector process|
|immune response-regulating cell surface receptor signaling pathway|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|inflammatory response|
|positive regulation of MAPK cascade|
|chemotaxis|
|taxis|
|cellular metal ion homeostasis|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|metal ion homeostasis|
|activation of immune response|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of cytokine production|
|regulation of protein transport|
|cation homeostasis|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|ion homeostasis|
|regulation of secretion|
|regulation of cell migration|
|positive regulation of immune response|
|cellular homeostasis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|locomotion|
|G protein-coupled receptor signaling pathway|
|defense response|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11190
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C5AR2 Expression in NALM6 Cells: 4.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>