======= CACNA1C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CACNA1C
  * **<color #00a2e8>Official Name</color>**: calcium voltage-gated channel subunit alpha1 C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=775|775]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13936|Q13936]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CACNA1C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CACNA1C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/114205|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ion trans|
|Ca chan IQ|
|PKD channel|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium ion transmembrane transport via high voltage-gated calcium channel|
|voltage-gated calcium channel activity involved in AV node cell action potential|
|membrane depolarization during atrial cardiac muscle cell action potential|
|calcium-mediated signaling using extracellular calcium source|
|voltage-gated calcium channel activity involved in cardiac muscle cell action potential|
|membrane depolarization during AV node cell action potential|
|AV node cell to bundle of His cell signaling|
|AV node cell action potential|
|positive regulation of adenylate cyclase activity|
|high voltage-gated calcium channel activity|
|AV node cell to bundle of His cell communication|
|L-type voltage-gated calcium channel complex|
|atrial cardiac muscle cell action potential|
|atrial cardiac muscle cell to AV node cell signaling|
|regulation of ventricular cardiac muscle cell action potential|
|atrial cardiac muscle cell to AV node cell communication|
|cell communication by electrical coupling involved in cardiac conduction|
|membrane depolarization during cardiac muscle cell action potential|
|alpha-actinin binding|
|cell communication by electrical coupling|
|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|
|positive regulation of cyclase activity|
|positive regulation of lyase activity|
|regulation of cardiac muscle contraction by calcium ion signaling|
|voltage-gated calcium channel complex|
|cell-cell signaling involved in cardiac conduction|
|regulation of adenylate cyclase activity|
|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|
|regulation of cardiac muscle cell action potential|
|membrane depolarization during action potential|
|embryonic forelimb morphogenesis|
|regulation of heart rate by cardiac conduction|
|regulation of cardiac muscle cell contraction|
|cardiac muscle cell action potential involved in contraction|
|voltage-gated calcium channel activity|
|forelimb morphogenesis|
|cardiac muscle cell contraction|
|regulation of actin filament-based movement|
|regulation of cyclase activity|
|calcium ion import|
|cell communication involved in cardiac conduction|
|regulation of lyase activity|
|cardiac muscle cell action potential|
|regulation of action potential|
|membrane depolarization|
|calcium ion transport into cytosol|
|regulation of cardiac muscle contraction|
|cardiac muscle contraction|
|regulation of release of sequestered calcium ion into cytosol|
|heart contraction|
|cytosolic calcium ion transport|
|actin-mediated cell contraction|
|regulation of striated muscle contraction|
|cardiac conduction|
|action potential|
|regulation of heart rate|
|regulation of calcium ion transport into cytosol|
|heart process|
|striated muscle contraction|
|actin filament-based movement|
|regulation of sequestering of calcium ion|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|Z disc|
|perikaryon|
|multicellular organismal signaling|
|calcium-mediated signaling|
|regulation of calcium ion transmembrane transport|
|limb morphogenesis|
|appendage morphogenesis|
|regulation of muscle contraction|
|regulation of insulin secretion|
|limb development|
|appendage development|
|calcium ion transmembrane transport|
|postsynaptic membrane|
|calmodulin binding|
|regulation of peptide hormone secretion|
|regulation of muscle system process|
|regulation of heart contraction|
|regulation of calcium ion transport|
|calcium ion transport|
|muscle contraction|
|postsynaptic density|
|regulation of hormone secretion|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|divalent metal ion transport|
|muscle system process|
|divalent inorganic cation transport|
|camera-type eye development|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|eye development|
|visual system development|
|sensory system development|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|blood circulation|
|circulatory system process|
|dendrite|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|heart development|
|regulation of hormone levels|
|sensory organ development|
|cell junction|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|embryonic morphogenesis|
|actin filament-based process|
|regulation of system process|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|immune system development|
|regulation of ion transport|
|cation homeostasis|
|regulation of protein transport|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|cation transport|
|circulatory system development|
|cellular homeostasis|
|regulation of cellular localization|
|ion transmembrane transport|
|embryo development|
|regulation of cellular component movement|
|regulation of protein localization|
|chemical homeostasis|
|cell-cell signaling|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|movement of cell or subcellular component|
|homeostatic process|
|intracellular signal transduction|
|positive regulation of molecular function|
|establishment of localization in cell|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4694
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CACNA1C Expression in NALM6 Cells: -0.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>