======= CACNG4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CACNG4
  * **<color #00a2e8>Official Name</color>**: calcium voltage-gated channel auxiliary subunit gamma 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27092|27092]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBN1|Q9UBN1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CACNG4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CACNG4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606404|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. {ECO:0000269|PubMed:21172611}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PMP22 Claudin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neurotransmitter receptor transport, postsynaptic endosome to lysosome|
|positive regulation of AMPA receptor activity|
|channel regulator activity|
|postsynaptic neurotransmitter receptor diffusion trapping|
|receptor diffusion trapping|
|neurotransmitter receptor diffusion trapping|
|L-type voltage-gated calcium channel complex|
|regulation of postsynaptic neurotransmitter receptor activity|
|somatodendritic compartment|
|protein localization to postsynaptic specialization membrane|
|neurotransmitter receptor internalization|
|neurotransmitter receptor localization to postsynaptic specialization membrane|
|positive regulation of glutamate receptor signaling pathway|
|postsynaptic density membrane|
|regulation of AMPA receptor activity|
|AMPA glutamate receptor complex|
|positive regulation of synaptic transmission, glutamatergic|
|ionotropic glutamate receptor binding|
|protein localization to postsynaptic membrane|
|positive regulation of signaling receptor activity|
|neurotransmitter receptor transport|
|calcium channel regulator activity|
|protein localization to lysosome|
|voltage-gated calcium channel activity|
|receptor localization to synapse|
|establishment of protein localization to vacuole|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|integral component of postsynaptic density membrane|
|membrane depolarization|
|response to cocaine|
|transmission of nerve impulse|
|protein localization to vacuole|
|receptor internalization|
|protein localization to synapse|
|regulation of glutamate receptor signaling pathway|
|endocytic vesicle membrane|
|positive regulation of cation channel activity|
|regulation of synaptic transmission, glutamatergic|
|cell body|
|regulation of neurotransmitter receptor activity|
|response to anesthetic|
|localization within membrane|
|cardiac conduction|
|positive regulation of ion transmembrane transporter activity|
|receptor metabolic process|
|lysosomal transport|
|positive regulation of transporter activity|
|response to alkaloid|
|multicellular organismal signaling|
|regulation of nervous system process|
|positive regulation of cation transmembrane transport|
|vacuolar transport|
|positive regulation of synaptic transmission|
|positive regulation of ion transmembrane transport|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|response to ammonium ion|
|calcium ion transmembrane transport|
|positive regulation of transmembrane transport|
|protein localization to cell periphery|
|receptor-mediated endocytosis|
|regulation of heart contraction|
|calcium ion transport|
|protein-containing complex localization|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|regulation of blood circulation|
|divalent metal ion transport|
|response to xenobiotic stimulus|
|divalent inorganic cation transport|
|regulation of cation transmembrane transport|
|glutamatergic synapse|
|regulation of membrane potential|
|establishment of protein localization to organelle|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|endocytosis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|regulation of system process|
|cation transmembrane transport|
|cell surface|
|metal ion transport|
|inorganic ion transmembrane transport|
|import into cell|
|regulation of ion transport|
|protein localization to organelle|
|cation transport|
|response to organic cyclic compound|
|ion transmembrane transport|
|positive regulation of transport|
|response to organonitrogen compound|
|response to drug|
|response to nitrogen compound|
|transmembrane transport|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of signal transduction|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9295
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CACNG4 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>