======= CAMSAP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CAMSAP3
  * **<color #00a2e8>Official Name</color>**: calmodulin regulated spectrin associated protein family member 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57662|57662]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P1Y5|Q9P1Y5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CAMSAP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CAMSAP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612685|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non- centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:27802168, PubMed:26715742). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non- centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391). {ECO:0000250|UniProtKB:Q80VC9, ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647, ECO:0000269|PubMed:24486153, ECO:0000269|PubMed:26715742, ECO:0000269|PubMed:27693509, ECO:0000269|PubMed:27802168, ECO:0000269|PubMed:28089391, ECO:0000269|PubMed:28386021}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CAMSAP CKK|
|CH|
|CAMSAP CH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|zonula adherens maintenance|
|establishment or maintenance of microtubule cytoskeleton polarity|
|adherens junction maintenance|
|microtubule minus-end|
|zonula adherens|
|cell-cell junction maintenance|
|microtubule minus-end binding|
|cell junction maintenance|
|epithelial cell-cell adhesion|
|regulation of Golgi organization|
|establishment of epithelial cell apical/basal polarity|
|establishment or maintenance of cytoskeleton polarity|
|polarized epithelial cell differentiation|
|establishment of apical/basal cell polarity|
|establishment of monopolar cell polarity|
|establishment or maintenance of monopolar cell polarity|
|negative regulation of microtubule depolymerization|
|microtubule anchoring|
|spectrin binding|
|regulation of microtubule depolymerization|
|establishment of epithelial cell polarity|
|negative regulation of microtubule polymerization or depolymerization|
|morphogenesis of a polarized epithelium|
|establishment or maintenance of epithelial cell apical/basal polarity|
|cellular component maintenance|
|establishment or maintenance of apical/basal cell polarity|
|establishment or maintenance of bipolar cell polarity|
|regulation of microtubule polymerization|
|cytoplasmic microtubule organization|
|regulation of cell-substrate junction assembly|
|regulation of focal adhesion assembly|
|negative regulation of protein depolymerization|
|microtubule-based protein transport|
|protein transport along microtubule|
|regulation of adherens junction organization|
|negative regulation of protein complex disassembly|
|regulation of microtubule polymerization or depolymerization|
|regulation of protein depolymerization|
|adherens junction organization|
|regulation of cell junction assembly|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|regulation of protein complex disassembly|
|regulation of cell-matrix adhesion|
|establishment of cell polarity|
|negative regulation of supramolecular fiber organization|
|cell-cell junction organization|
|negative regulation of cytoskeleton organization|
|transport along microtubule|
|cytoskeleton-dependent intracellular transport|
|regulation of phosphatase activity|
|microtubule-based transport|
|regulation of microtubule cytoskeleton organization|
|establishment or maintenance of cell polarity|
|calmodulin binding|
|actin filament binding|
|regulation of dephosphorylation|
|regulation of cell-substrate adhesion|
|cell junction organization|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|microtubule-based movement|
|regulation of supramolecular fiber organization|
|negative regulation of organelle organization|
|in utero embryonic development|
|morphogenesis of an epithelium|
|regulation of protein complex assembly|
|negative regulation of hydrolase activity|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|centrosome|
|cell-cell adhesion|
|regulation of cytoskeleton organization|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|tissue morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|neuron projection development|
|microtubule-based process|
|regulation of cell adhesion|
|epithelial cell differentiation|
|negative regulation of cellular component organization|
|negative regulation of catalytic activity|
|neuron development|
|regulation of cell migration|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|regulation of cellular component biogenesis|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|intracellular protein transport|
|neuron differentiation|
|cytoskeleton organization|
|epithelium development|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|regulation of hydrolase activity|
|regulation of organelle organization|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|cell development|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8872
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CAMSAP3 Expression in NALM6 Cells: -3.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>