======= CAPN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CAPN2
  * **<color #00a2e8>Official Name</color>**: calpain 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=824|824]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17655|P17655]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CAPN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CAPN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/114230|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity). {ECO:0000250|UniProtKB:O08529, ECO:0000269|PubMed:17650508}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Calpain III|
|Peptidase C2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of phosphatidylcholine biosynthetic process|
|regulation of phosphatidylcholine biosynthetic process|
|positive regulation of phospholipid biosynthetic process|
|positive regulation of striated muscle cell apoptotic process|
|positive regulation of cardiac muscle cell apoptotic process|
|behavioral response to pain|
|protein autoprocessing|
|regulation of phospholipid biosynthetic process|
|calcium-dependent cysteine-type endopeptidase activity|
|perinuclear endoplasmic reticulum|
|pseudopodium|
|positive regulation of myoblast fusion|
|cellular response to interferon-beta|
|regulation of myoblast fusion|
|myoblast fusion|
|positive regulation of syncytium formation by plasma membrane fusion|
|positive regulation of muscle cell apoptotic process|
|response to interferon-beta|
|regulation of syncytium formation by plasma membrane fusion|
|cysteine-type peptidase activity|
|response to pain|
|positive regulation of myotube differentiation|
|cell-cell fusion|
|syncytium formation by plasma membrane fusion|
|regulation of cardiac muscle cell apoptotic process|
|syncytium formation|
|regulation of striated muscle cell apoptotic process|
|positive regulation of phospholipid metabolic process|
|cortical actin cytoskeleton|
|myotube differentiation|
|regulation of myotube differentiation|
|positive regulation of striated muscle cell differentiation|
|extracellular matrix disassembly|
|multicellular organismal response to stress|
|regulation of muscle cell apoptotic process|
|cellular response to amino acid stimulus|
|cytoskeletal protein binding|
|mitochondrial intermembrane space|
|positive regulation of lipid biosynthetic process|
|regulation of phospholipid metabolic process|
|positive regulation of muscle cell differentiation|
|positive regulation of neuron death|
|blastocyst development|
|regulation of striated muscle cell differentiation|
|chromatin|
|response to amino acid|
|response to hydrogen peroxide|
|regulation of interleukin-6 production|
|positive regulation of lipid metabolic process|
|regulation of muscle cell differentiation|
|protein processing|
|female pregnancy|
|cellular response to lipopolysaccharide|
|regulation of lipid biosynthetic process|
|cellular response to molecule of bacterial origin|
|response to reactive oxygen species|
|striated muscle cell differentiation|
|cellular response to acid chemical|
|multi-multicellular organism process|
|cellular response to biotic stimulus|
|protein maturation|
|membrane raft|
|muscle cell differentiation|
|lysosome|
|response to antibiotic|
|regulation of neuron death|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|extracellular matrix organization|
|response to hypoxia|
|response to acid chemical|
|enzyme binding|
|response to decreased oxygen levels|
|neuronal cell body|
|in utero embryonic development|
|response to oxygen levels|
|extracellular structure organization|
|response to oxidative stress|
|external side of plasma membrane|
|regulation of lipid metabolic process|
|cellular component disassembly|
|focal adhesion|
|dendrite|
|muscle structure development|
|protein heterodimerization activity|
|response to toxic substance|
|cellular response to lipid|
|response to inorganic substance|
|regulation of cytoskeleton organization|
|behavior|
|proteolysis involved in cellular protein catabolic process|
|cellular response to organonitrogen compound|
|cellular protein catabolic process|
|chordate embryonic development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|cellular response to nitrogen compound|
|protein catabolic process|
|response to bacterium|
|regulation of cytokine production|
|positive regulation of cell death|
|calcium ion binding|
|response to lipid|
|anatomical structure formation involved in morphogenesis|
|cellular macromolecule catabolic process|
|positive regulation of cell differentiation|
|embryo development|
|Golgi apparatus|
|multi-organism reproductive process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|response to drug|
|macromolecule catabolic process|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|response to cytokine|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|proteolysis|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of cell death|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cellular biosynthetic process|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.71|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7090
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CAPN2 Expression in NALM6 Cells: 2.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>