======= CAPRIN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CAPRIN1
  * **<color #00a2e8>Official Name</color>**: cell cycle associated protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4076|4076]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14444|Q14444]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CAPRIN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CAPRIN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601178|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs. {ECO:0000269|PubMed:17210633}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Caprin-1 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of dendritic spine morphogenesis|
|positive regulation of dendrite morphogenesis|
|regulation of dendritic spine morphogenesis|
|positive regulation of dendritic spine development|
|cytoplasmic stress granule|
|regulation of dendritic spine development|
|positive regulation of dendrite development|
|P-body|
|regulation of dendrite morphogenesis|
|regulation of postsynapse organization|
|negative regulation of translation|
|negative regulation of cellular amide metabolic process|
|regulation of dendrite development|
|positive regulation of cell morphogenesis involved in differentiation|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|synapse|
|positive regulation of neuron projection development|
|regulation of cell morphogenesis involved in differentiation|
|regulation of translation|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|regulation of cellular amide metabolic process|
|dendrite|
|positive regulation of neurogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|posttranscriptional regulation of gene expression|
|positive regulation of nervous system development|
|positive regulation of cell development|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of neurogenesis|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|negative regulation of cellular protein metabolic process|
|regulation of anatomical structure morphogenesis|
|negative regulation of protein metabolic process|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|negative regulation of biosynthetic process|
|neurogenesis|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-3.45|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.85|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.83|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.78|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.77|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.76|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.75|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.75|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.73|
|[[:results:exp539|42°C R08 exp539]]|1.75|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.8|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.82|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.84|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.91|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.92|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.92|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.94|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.97|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.24|
|[[:results:exp518|RK-33 8μM R08 exp518]]|2.29|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.36|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.39|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3535
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CAPRIN1 Expression in NALM6 Cells: 8.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>