======= CARS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CARS1
  * **<color #00a2e8>Official Name</color>**: cysteinyl-tRNA synthetase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=833|833]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49589|P49589]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CARS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CARS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/123859|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|tRNA-synt 1e|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cysteine-tRNA ligase activity|
|cysteinyl-tRNA aminoacylation|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|tRNA binding|
|tRNA metabolic process|
|cellular amino acid metabolic process|
|translation|
|peptide biosynthetic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|protein homodimerization activity|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.75|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.75|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.96|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.18|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|2.22|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.57|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.68|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.642|
|[[:human genes:m:mars|MARS]]|0.557|
|[[:human genes:h:hspd1|HSPD1]]|0.523|
|[[:human genes:g:gmppb|GMPPB]]|0.511|
|[[:human genes:r:rnmt|RNMT]]|0.485|
|[[:human genes:g:gfpt1|GFPT1]]|0.481|
|[[:human genes:n:nars|NARS]]|0.477|
|[[:human genes:a:alg2|ALG2]]|0.474|
|[[:human genes:m:meaf6|MEAF6]]|0.456|
|[[:human genes:n:nae1|NAE1]]|0.455|
|[[:human genes:c:csnk2b|CSNK2B]]|0.448|
|[[:human genes:t:tsen34|TSEN34]]|0.444|
|[[:human genes:s:srp72|SRP72]]|0.44|
|[[:human genes:r:rtcb|RTCB]]|0.44|
|[[:human genes:s:smarcd1|SMARCD1]]|0.437|
|[[:human genes:v:vmp1|VMP1]]|0.436|
|[[:human genes:s:spcs3|SPCS3]]|0.435|
|[[:human genes:e:eny2|ENY2]]|0.433|
|[[:human genes:e:eprs|EPRS]]|0.431|
|[[:human genes:p:pmm2|PMM2]]|0.429|
|[[:human genes:c:cct7|CCT7]]|0.427|
|[[:human genes:s:slc35b1|SLC35B1]]|0.426|
|[[:human genes:p:pam16|PAM16]]|0.425|
|[[:human genes:u:uba3|UBA3]]|0.425|
|[[:human genes:p:pelo|PELO]]|0.424|
|[[:human genes:c:casp9|CASP9]]|0.422|
|[[:human genes:n:nsmce2|NSMCE2]]|0.421|
|[[:human genes:s:seh1l|SEH1L]]|0.42|
|[[:human genes:y:yars|YARS]]|0.419|
|[[:human genes:t:triap1|TRIAP1]]|0.418|
|[[:human genes:r:rptor|RPTOR]]|0.418|
|[[:human genes:h:hspa9|HSPA9]]|0.416|
|[[:human genes:c:ccdc101|CCDC101]]|0.415|
|[[:human genes:e:eif4e|EIF4E]]|0.415|
|[[:human genes:o:otud5|OTUD5]]|0.412|
|[[:human genes:a:apaf1|APAF1]]|0.412|
|[[:human genes:a:aars|AARS]]|0.412|
|[[:human genes:a:alg11|ALG11]]|0.41|
|[[:human genes:u:ube2l3|UBE2L3]]|0.409|
|[[:human genes:m:mtor|MTOR]]|0.408|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.407|
|[[:human genes:d:dhps|DHPS]]|0.406|
|[[:human genes:m:mllt1|MLLT1]]|0.404|
|[[:human genes:d:dpagt1|DPAGT1]]|0.403|
|[[:human genes:u:uap1|UAP1]]|0.4|
|[[:human genes:p:polr3b|POLR3B]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 727/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|24/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|20/21|
|liver|20/20|
|lung|73/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|23/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 207
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CARS Expression in NALM6 Cells: 6.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>