======= CARS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CARS2
  * **<color #00a2e8>Official Name</color>**: cysteinyl-tRNA synthetase 2, mitochondrial
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79587|79587]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HA77|Q9HA77]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CARS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CARS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612800|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a putative member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of cysteine to tRNA molecules. A splice-site mutation in this gene has been associated with a novel progressive myoclonic epilepsy disease with similar symptoms to MERRF syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|tRNA-synt 1e|
|tRNA-synt 1g|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cysteine-tRNA ligase activity|
|cysteinyl-tRNA aminoacylation|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|tRNA metabolic process|
|cellular amino acid metabolic process|
|mitochondrial matrix|
|translation|
|peptide biosynthetic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.7|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.7|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.74|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.74|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.76|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.85|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.03|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.84|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nars2|NARS2]]|0.616|
|[[:human genes:l:lars2|LARS2]]|0.615|
|[[:human genes:p:pet117|PET117]]|0.612|
|[[:human genes:t:tfb1m|TFB1M]]|0.603|
|[[:human genes:s:selrc1|SELRC1]]|0.581|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.576|
|[[:human genes:q:qrsl1|QRSL1]]|0.571|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.568|
|[[:human genes:n:ndufa1|NDUFA1]]|0.561|
|[[:human genes:p:pet112|PET112]]|0.56|
|[[:human genes:m:mrpl45|MRPL45]]|0.559|
|[[:human genes:r:rpusd3|RPUSD3]]|0.558|
|[[:human genes:c:coa6|COA6]]|0.558|
|[[:human genes:m:mrps25|MRPS25]]|0.553|
|[[:human genes:f:ftsj2|FTSJ2]]|0.552|
|[[:human genes:d:dars2|DARS2]]|0.55|
|[[:human genes:n:ndufs2|NDUFS2]]|0.55|
|[[:human genes:m:mrps21|MRPS21]]|0.546|
|[[:human genes:m:mrps27|MRPS27]]|0.546|
|[[:human genes:m:mrps16|MRPS16]]|0.545|
|[[:human genes:c:coa3|COA3]]|0.544|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.543|
|[[:human genes:n:ndufa3|NDUFA3]]|0.542|
|[[:human genes:m:malsu1|MALSU1]]|0.534|
|[[:human genes:p:polg2|POLG2]]|0.533|
|[[:human genes:e:ears2|EARS2]]|0.53|
|[[:human genes:t:tefm|TEFM]]|0.525|
|[[:human genes:m:mtif2|MTIF2]]|0.525|
|[[:human genes:g:grsf1|GRSF1]]|0.524|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.523|
|[[:human genes:a:acad9|ACAD9]]|0.522|
|[[:human genes:d:dap3|DAP3]]|0.521|
|[[:human genes:f:fastkd2|FASTKD2]]|0.521|
|[[:human genes:p:pnpt1|PNPT1]]|0.521|
|[[:human genes:m:mrps26|MRPS26]]|0.52|
|[[:human genes:m:mrpl21|MRPL21]]|0.519|
|[[:human genes:y:yars2|YARS2]]|0.519|
|[[:human genes:n:ndufc2|NDUFC2]]|0.519|
|[[:human genes:g:gfm1|GFM1]]|0.519|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.517|
|[[:human genes:r:rars2|RARS2]]|0.516|
|[[:human genes:t:tars2|TARS2]]|0.516|
|[[:human genes:n:ndufb10|NDUFB10]]|0.515|
|[[:human genes:n:ndufv1|NDUFV1]]|0.514|
|[[:human genes:p:pars2|PARS2]]|0.514|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.512|
|[[:human genes:e:eral1|ERAL1]]|0.509|
|[[:human genes:r:rpusd4|RPUSD4]]|0.509|
|[[:human genes:m:mrps6|MRPS6]]|0.508|
|[[:human genes:m:mars2|MARS2]]|0.508|
|[[:human genes:n:ndufb11|NDUFB11]]|0.507|
|[[:human genes:t:tmem261|TMEM261]]|0.506|
|[[:human genes:g:gfm2|GFM2]]|0.506|
|[[:human genes:v:vars2|VARS2]]|0.505|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.502|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.501|
|[[:human genes:s:ssbp1|SSBP1]]|0.497|
|[[:human genes:n:ndufs5|NDUFS5]]|0.495|
|[[:human genes:n:nubpl|NUBPL]]|0.494|
|[[:human genes:r:rmnd1|RMND1]]|0.493|
|[[:human genes:m:mrp63|MRP63]]|0.489|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.489|
|[[:human genes:a:aars2|AARS2]]|0.488|
|[[:human genes:d:ddx28|DDX28]]|0.487|
|[[:human genes:a:atp5sl|ATP5SL]]|0.483|
|[[:human genes:m:mrpl20|MRPL20]]|0.483|
|[[:human genes:n:ndufa2|NDUFA2]]|0.482|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.482|
|[[:human genes:m:mterfd1|MTERFD1]]|0.481|
|[[:human genes:m:mrps5|MRPS5]]|0.48|
|[[:human genes:s:sco2|SCO2]]|0.479|
|[[:human genes:w:wars2|WARS2]]|0.478|
|[[:human genes:r:rbfa|RBFA]]|0.478|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.477|
|[[:human genes:m:mrps14|MRPS14]]|0.475|
|[[:human genes:c:cox11|COX11]]|0.472|
|[[:human genes:m:mrpl53|MRPL53]]|0.469|
|[[:human genes:n:ndufs1|NDUFS1]]|0.467|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.467|
|[[:human genes:m:mrpl17|MRPL17]]|0.466|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.466|
|[[:human genes:p:ptcd3|PTCD3]]|0.463|
|[[:human genes:m:mrpl49|MRPL49]]|0.463|
|[[:human genes:n:nsun4|NSUN4]]|0.463|
|[[:human genes:m:mto1|MTO1]]|0.462|
|[[:human genes:m:mrps12|MRPS12]]|0.462|
|[[:human genes:n:ndufa11|NDUFA11]]|0.462|
|[[:human genes:n:ndufs7|NDUFS7]]|0.462|
|[[:human genes:c:chchd1|CHCHD1]]|0.461|
|[[:human genes:m:mettl17|METTL17]]|0.46|
|[[:human genes:t:trub2|TRUB2]]|0.46|
|[[:human genes:m:mrpl47|MRPL47]]|0.46|
|[[:human genes:c:coq2|COQ2]]|0.457|
|[[:human genes:m:mrps18b|MRPS18B]]|0.456|
|[[:human genes:l:lrpprc|LRPPRC]]|0.454|
|[[:human genes:c:cox16|COX16]]|0.453|
|[[:human genes:w:wbscr16|WBSCR16]]|0.452|
|[[:human genes:m:mrpl44|MRPL44]]|0.452|
|[[:human genes:m:mrps34|MRPS34]]|0.452|
|[[:human genes:c:cox15|COX15]]|0.452|
|[[:human genes:f:fastkd5|FASTKD5]]|0.451|
|[[:human genes:m:mrpl3|MRPL3]]|0.449|
|[[:human genes:c:c1qbp|C1QBP]]|0.447|
|[[:human genes:m:mrpl1|MRPL1]]|0.447|
|[[:human genes:n:ndufa8|NDUFA8]]|0.446|
|[[:human genes:n:ndufb6|NDUFB6]]|0.445|
|[[:human genes:p:polrmt|POLRMT]]|0.445|
|[[:human genes:c:c12orf65|C12orf65]]|0.444|
|[[:human genes:m:mcat|MCAT]]|0.442|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.442|
|[[:human genes:c:c10orf2|C10orf2]]|0.441|
|[[:human genes:h:hars2|HARS2]]|0.441|
|[[:human genes:g:gatc|GATC]]|0.441|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.44|
|[[:human genes:n:ndufb9|NDUFB9]]|0.439|
|[[:human genes:m:mrps24|MRPS24]]|0.439|
|[[:human genes:n:ndufb5|NDUFB5]]|0.439|
|[[:human genes:n:ndufc1|NDUFC1]]|0.438|
|[[:human genes:m:mrpl39|MRPL39]]|0.438|
|[[:human genes:n:ndufs8|NDUFS8]]|0.438|
|[[:human genes:m:mrpl28|MRPL28]]|0.436|
|[[:human genes:p:polg|POLG]]|0.436|
|[[:human genes:p:prepl|PREPL]]|0.436|
|[[:human genes:e:ecsit|ECSIT]]|0.436|
|[[:human genes:b:bcs1l|BCS1L]]|0.432|
|[[:human genes:m:mtg1|MTG1]]|0.427|
|[[:human genes:m:mrps18a|MRPS18A]]|0.427|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.426|
|[[:human genes:m:mrps22|MRPS22]]|0.425|
|[[:human genes:m:mrpl51|MRPL51]]|0.425|
|[[:human genes:c:clpp|CLPP]]|0.42|
|[[:human genes:m:mterfd2|MTERFD2]]|0.42|
|[[:human genes:m:mrpl11|MRPL11]]|0.42|
|[[:human genes:m:mrpl15|MRPL15]]|0.419|
|[[:human genes:m:mrps9|MRPS9]]|0.417|
|[[:human genes:f:foxred1|FOXRED1]]|0.417|
|[[:human genes:m:mtrf1|MTRF1]]|0.417|
|[[:human genes:m:mtg2|MTG2]]|0.416|
|[[:human genes:m:mrps10|MRPS10]]|0.415|
|[[:human genes:f:fars2|FARS2]]|0.413|
|[[:human genes:c:cox20|COX20]]|0.413|
|[[:human genes:m:mtif3|MTIF3]]|0.413|
|[[:human genes:m:mrpl18|MRPL18]]|0.413|
|[[:human genes:c:cox18|COX18]]|0.411|
|[[:human genes:m:mrpl23|MRPL23]]|0.411|
|[[:human genes:p:ptcd1|PTCD1]]|0.41|
|[[:human genes:m:mrpl22|MRPL22]]|0.409|
|[[:human genes:a:aifm1|AIFM1]]|0.409|
|[[:human genes:m:mrpl35|MRPL35]]|0.409|
|[[:human genes:m:mrpl42|MRPL42]]|0.408|
|[[:human genes:m:mrpl43|MRPL43]]|0.408|
|[[:human genes:n:ndufb7|NDUFB7]]|0.408|
|[[:human genes:m:mrpl4|MRPL4]]|0.408|
|[[:human genes:c:cox6b1|COX6B1]]|0.407|
|[[:human genes:m:mrps7|MRPS7]]|0.407|
|[[:human genes:n:ndufa5|NDUFA5]]|0.406|
|[[:human genes:m:mrpl12|MRPL12]]|0.405|
|[[:human genes:n:ndufb4|NDUFB4]]|0.404|
|[[:human genes:m:mrps23|MRPS23]]|0.401|
|[[:human genes:m:mrps33|MRPS33]]|0.401|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.401|
|[[:human genes:m:mrpl37|MRPL37]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 9/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 689
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CARS2 Expression in NALM6 Cells: 5.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>