======= CASP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CASP1
  * **<color #00a2e8>Official Name</color>**: caspase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=834|834]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P29466|P29466]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CASP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CASP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147678|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive (PubMed:28314590). {ECO:0000269|PubMed:15498465, ECO:0000269|PubMed:1574116, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:7876192}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CARD|
|Peptidase C14|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protease inhibitor complex|
|IPAF inflammasome complex|
|AIM2 inflammasome complex|
|NLRP1 inflammasome complex|
|NLRP3 inflammasome complex|
|cysteine-type endopeptidase activity involved in apoptotic signaling pathway|
|positive regulation of tumor necrosis factor-mediated signaling pathway|
|cysteine-type endopeptidase activity involved in apoptotic process|
|cysteine-type endopeptidase activator activity involved in apoptotic process|
|protein autoprocessing|
|CARD domain binding|
|positive regulation of interleukin-1 beta secretion|
|positive regulation of interleukin-1 secretion|
|regulation of interleukin-1 beta secretion|
|positive regulation of cytokine-mediated signaling pathway|
|positive regulation of interleukin-1 beta production|
|execution phase of apoptosis|
|regulation of interleukin-1 secretion|
|positive regulation of response to cytokine stimulus|
|positive regulation of interleukin-1 production|
|regulation of tumor necrosis factor-mediated signaling pathway|
|endopeptidase activity|
|cellular response to mechanical stimulus|
|regulation of interleukin-1 beta production|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|cysteine-type endopeptidase activity|
|kinase binding|
|regulation of interleukin-1 production|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of cytokine secretion|
|positive regulation of cysteine-type endopeptidase activity|
|protein processing|
|cellular response to interferon-gamma|
|regulation of cytokine-mediated signaling pathway|
|positive regulation of endopeptidase activity|
|regulation of response to cytokine stimulus|
|response to interferon-gamma|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|cellular response to lipopolysaccharide|
|positive regulation of peptidase activity|
|cellular response to molecule of bacterial origin|
|regulation of cytokine secretion|
|response to mechanical stimulus|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|cellular response to biotic stimulus|
|protein maturation|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of cysteine-type endopeptidase activity|
|positive regulation of protein secretion|
|apoptotic signaling pathway|
|positive regulation of peptide secretion|
|response to lipopolysaccharide|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|response to molecule of bacterial origin|
|cellular response to external stimulus|
|positive regulation of proteolysis|
|positive regulation of secretion by cell|
|regulation of endopeptidase activity|
|positive regulation of protein transport|
|positive regulation of secretion|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of peptide secretion|
|cellular response to lipid|
|protein-containing complex|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|cytokine-mediated signaling pathway|
|response to bacterium|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|innate immune response|
|positive regulation of hydrolase activity|
|regulation of secretion|
|response to lipid|
|apoptotic process|
|defense response to other organism|
|positive regulation of transport|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|programmed cell death|
|cellular response to oxygen-containing compound|
|identical protein binding|
|cell death|
|response to cytokine|
|response to abiotic stimulus|
|proteolysis|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
|immune response|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17990
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CASP1 Expression in NALM6 Cells: 1.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>