======= CCDC155 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KASH5
  * **<color #00a2e8>Official Name</color>**: KASH domain containing 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=147872|147872]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N6L0|Q8N6L0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCDC155&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCDC155|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618125|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homologue pairing during meiotic prophase in spermatocytes and probably oocytes. Essential for male and female gametogenesis. Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes. In oocytes is involved in meiotic resumption and spindle formation. {ECO:0000250|UniProtKB:Q80VJ8}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|microtubule cytoskeleton organization involved in homologous chromosome segregation|
|meiotic spindle pole|
|meiotic nuclear membrane microtubule tethering complex|
|chromosome localization to nuclear envelope involved in homologous chromosome segregation|
|lateral element|
|telomere localization|
|dynein complex binding|
|nuclear outer membrane|
|synapsis|
|spindle localization|
|chromosome, telomeric region|
|homologous chromosome segregation|
|chromosome organization involved in meiotic cell cycle|
|establishment of chromosome localization|
|chromosome localization|
|oogenesis|
|meiotic chromosome segregation|
|double-strand break repair via homologous recombination|
|recombinational repair|
|spindle assembly|
|meiosis I|
|meiosis I cell cycle process|
|female gamete generation|
|meiotic nuclear division|
|spindle organization|
|meiotic cell cycle process|
|double-strand break repair|
|nuclear chromosome segregation|
|DNA recombination|
|meiotic cell cycle|
|actin filament organization|
|germ cell development|
|chromosome segregation|
|nuclear division|
|organelle fission|
|cellular process involved in reproduction in multicellular organism|
|establishment of organelle localization|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|actin cytoskeleton organization|
|DNA repair|
|spermatogenesis|
|male gamete generation|
|actin filament-based process|
|organelle localization|
|developmental process involved in reproduction|
|microtubule-based process|
|gamete generation|
|DNA metabolic process|
|organelle assembly|
|cellular response to DNA damage stimulus|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|multi-organism reproductive process|
|cell cycle process|
|chromosome organization|
|identical protein binding|
|cytoskeleton organization|
|cell cycle|
|reproductive process|
|reproduction|
|cell development|
|cellular response to stress|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-1.88|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-1.8|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.75|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-1.7|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|1.7|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.81|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.91|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|1.99|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7024
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCDC155 Expression in NALM6 Cells: -1.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>