======= CCDC23 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SVBP
  * **<color #00a2e8>Official Name</color>**: small vasohibin binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=374969|374969]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N300|Q8N300]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCDC23&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCDC23|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617853|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Enhances the solubility and secretion of VASH1 and prevents its ubiquitination. Also enhances secretion of VASH2. {ECO:0000269|PubMed:20736312}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of endothelial cell migration|
|negative regulation of epithelial cell migration|
|apical part of cell|
|negative regulation of protein ubiquitination|
|negative regulation of protein modification by small protein conjugation or removal|
|regulation of endothelial cell migration|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|peptide secretion|
|regulation of protein ubiquitination|
|regulation of epithelial cell migration|
|regulation of protein modification by small protein conjugation or removal|
|negative regulation of cell migration|
|negative regulation of cell motility|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|negative regulation of protein modification process|
|regulation of cell migration|
|regulation of cell motility|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|negative regulation of cellular protein metabolic process|
|export from cell|
|negative regulation of protein metabolic process|
|secretion|
|negative regulation of multicellular organismal process|
|proteolysis|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|regulation of protein modification process|
|nitrogen compound transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-2.18|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|-1.95|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15982
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCDC23 Expression in NALM6 Cells: 2.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>