======= CCDC53 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WASHC3
  * **<color #00a2e8>Official Name</color>**: WASH complex subunit 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51019|51019]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3C0|Q9Y3C0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCDC53&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCDC53|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619925|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093). {ECO:0000269|PubMed:19922875, ECO:0000269|PubMed:20498093}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF2360|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|WASH complex|
|actin filament polymerization|
|actin polymerization or depolymerization|
|protein polymerization|
|actin filament organization|
|early endosome|
|supramolecular fiber organization|
|actin cytoskeleton organization|
|actin filament-based process|
|exocytosis|
|cellular protein-containing complex assembly|
|secretion by cell|
|export from cell|
|cytoskeleton organization|
|secretion|
|protein transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|establishment of protein localization|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.91|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.83|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.82|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.76|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.71|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kiaa0196|KIAA0196]]|0.579|
|[[:human genes:k:kiaa1033|KIAA1033]]|0.577|
|[[:human genes:c:ccdc22|CCDC22]]|0.534|
|[[:human genes:v:vps45|VPS45]]|0.506|
|[[:human genes:a:actr3|ACTR3]]|0.485|
|[[:human genes:r:rab7a|RAB7A]]|0.481|
|[[:human genes:c:commd10|COMMD10]]|0.475|
|[[:human genes:c:commd5|COMMD5]]|0.46|
|[[:human genes:c:commd3|COMMD3]]|0.451|
|[[:human genes:a:arpc4|ARPC4]]|0.449|
|[[:human genes:a:arpc2|ARPC2]]|0.439|
|[[:human genes:v:vps29|VPS29]]|0.423|
|[[:human genes:c:commd7|COMMD7]]|0.422|
|[[:human genes:c:commd9|COMMD9]]|0.421|
|[[:human genes:c:commd2|COMMD2]]|0.421|
|[[:human genes:a:actr2|ACTR2]]|0.421|
|[[:human genes:h:h2afz|H2AFZ]]|0.42|
|[[:human genes:r:rab21|RAB21]]|0.418|
|[[:human genes:c:commd8|COMMD8]]|0.413|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 9/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|3/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8158
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCDC53 Expression in NALM6 Cells: 3.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>