======= CCT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCT2
  * **<color #00a2e8>Official Name</color>**: chaperonin containing TCP1 subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10576|10576]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78371|P78371]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605139|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. {ECO:0000269|PubMed:20080638}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cpn60 TCP1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chaperone mediated protein folding independent of cofactor|
|RNA localization to Cajal body|
|scaRNA localization to Cajal body|
|RNA localization to nucleus|
|zona pellucida receptor complex|
|positive regulation of protein localization to Cajal body|
|regulation of protein localization to Cajal body|
|positive regulation of establishment of protein localization to telomere|
|regulation of establishment of protein localization to telomere|
|chaperonin-containing T-complex|
|regulation of establishment of protein localization to chromosome|
|positive regulation of protein localization to chromosome, telomeric region|
|regulation of protein localization to chromosome, telomeric region|
|positive regulation of telomerase RNA localization to Cajal body|
|chaperone-mediated protein complex assembly|
|regulation of telomerase RNA localization to Cajal body|
|protein folding chaperone|
|positive regulation of telomere maintenance via telomerase|
|binding of sperm to zona pellucida|
|positive regulation of telomerase activity|
|positive regulation of telomere maintenance via telomere lengthening|
|de novo posttranslational protein folding|
|toxin transport|
|de novo protein folding|
|positive regulation of telomere maintenance|
|sperm-egg recognition|
|regulation of telomerase activity|
|regulation of telomere maintenance via telomerase|
|chaperone-mediated protein folding|
|regulation of telomere maintenance via telomere lengthening|
|positive regulation of DNA biosynthetic process|
|cell-cell recognition|
|cell body|
|positive regulation of protein localization to nucleus|
|regulation of telomere maintenance|
|azurophil granule lumen|
|regulation of DNA biosynthetic process|
|regulation of protein localization to nucleus|
|unfolded protein binding|
|single fertilization|
|fertilization|
|positive regulation of chromosome organization|
|protein stabilization|
|positive regulation of DNA metabolic process|
|RNA localization|
|protein folding|
|cell recognition|
|regulation of protein stability|
|ubiquitin protein ligase binding|
|microtubule|
|positive regulation of cellular protein localization|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|positive regulation of establishment of protein localization|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of cellular protein localization|
|myeloid leukocyte activation|
|positive regulation of organelle organization|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|positive regulation of transferase activity|
|regulated exocytosis|
|regulation of establishment of protein localization|
|leukocyte mediated immunity|
|exocytosis|
|sexual reproduction|
|cellular protein-containing complex assembly|
|regulation of cellular localization|
|leukocyte activation|
|regulation of transferase activity|
|multi-organism reproductive process|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|ATP binding|
|protein-containing complex assembly|
|positive regulation of molecular function|
|protein-containing complex subunit organization|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.86|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-2.74|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2|
|[[:results:exp136|MS094 2μM R03 exp136]]|-1.78|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.74|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.7|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.73|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.86|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.88|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.93|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|2.02|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|2.02|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.04|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|2.14|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|2.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.517|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 692/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|26/28|
|bone|26/26|
|breast|31/33|
|central nervous system|51/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|19/21|
|liver|16/20|
|lung|71/75|
|lymphocyte|15/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|13/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 455
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCT2 Expression in NALM6 Cells: 8.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>