======= CD3E =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD3E
  * **<color #00a2e8>Official Name</color>**: CD3e molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=916|916]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07766|P07766]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD3E&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD3E|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/186830|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell developement. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down- regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128). {ECO:0000269|PubMed:10384095, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:15546002, ECO:0000269|PubMed:2470098, ECO:0000269|PubMed:26507128, ECO:0000269|PubMed:8490660}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ITAM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of T cell anergy|
|positive regulation of lymphocyte anergy|
|regulation of lymphocyte anergy|
|regulation of T cell anergy|
|alpha-beta T cell receptor complex|
|positive regulation of cell-cell adhesion mediated by integrin|
|positive regulation of T cell tolerance induction|
|T cell receptor binding|
|signal complex assembly|
|positive regulation of tolerance induction|
|regulation of T cell tolerance induction|
|positive thymic T cell selection|
|negative thymic T cell selection|
|regulation of cell-cell adhesion mediated by integrin|
|negative T cell selection|
|positive regulation of interleukin-2 biosynthetic process|
|regulation of tolerance induction|
|thymic T cell selection|
|positive regulation of alpha-beta T cell proliferation|
|regulation of interleukin-2 biosynthetic process|
|positive regulation of cell adhesion mediated by integrin|
|receptor signaling complex adaptor activity|
|positive regulation of interleukin-4 production|
|positive T cell selection|
|regulation of interleukin-4 production|
|negative regulation of smoothened signaling pathway|
|positive regulation of interleukin-2 production|
|regulation of alpha-beta T cell proliferation|
|immunological synapse|
|T cell selection|
|positive regulation of calcium-mediated signaling|
|regulation of cell adhesion mediated by integrin|
|T cell differentiation in thymus|
|positive regulation of cell-matrix adhesion|
|T cell costimulation|
|regulation of interleukin-2 production|
|lymphocyte costimulation|
|positive regulation of alpha-beta T cell activation|
|positive regulation of interferon-gamma production|
|positive regulation of cytokine biosynthetic process|
|cell body|
|regulation of smoothened signaling pathway|
|regulation of alpha-beta T cell activation|
|positive regulation of T cell proliferation|
|regulation of calcium-mediated signaling|
|regulation of interferon-gamma production|
|cerebellum development|
|dendrite development|
|regulation of cytokine biosynthetic process|
|metencephalon development|
|regulation of cell-matrix adhesion|
|positive regulation of cell-substrate adhesion|
|T cell receptor complex|
|positive regulation of lymphocyte proliferation|
|SH3 domain binding|
|positive regulation of mononuclear cell proliferation|
|T cell differentiation|
|positive regulation of leukocyte proliferation|
|transmembrane signaling receptor activity|
|dendritic spine|
|hindbrain development|
|regulation of T cell proliferation|
|cell-cell junction|
|T cell receptor signaling pathway|
|positive regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of T cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of cell-substrate adhesion|
|response to nutrient|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|T cell activation|
|lymphocyte differentiation|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|apoptotic signaling pathway|
|antigen receptor-mediated signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|leukocyte differentiation|
|protein homooligomerization|
|positive regulation of lymphocyte activation|
|lymphocyte activation|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of cytokine production|
|protein kinase binding|
|immune response-regulating cell surface receptor signaling pathway|
|protein heterodimerization activity|
|response to nutrient levels|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of lymphocyte activation|
|protein complex oligomerization|
|response to extracellular stimulus|
|hemopoiesis|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|activation of immune response|
|regulation of cell activation|
|immune system development|
|neuron projection development|
|regulation of cell adhesion|
|regulation of cytokine production|
|enzyme linked receptor protein signaling pathway|
|brain development|
|head development|
|neuron development|
|cellular protein-containing complex assembly|
|positive regulation of immune response|
|protein homodimerization activity|
|positive regulation of cell population proliferation|
|apoptotic process|
|leukocyte activation|
|central nervous system development|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|positive regulation of phosphorylation|
|cell activation|
|cell death|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|cell projection organization|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|generation of neurons|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.74|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|1.7|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12594
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD3E Expression in NALM6 Cells: -3.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>