======= CD52 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD52
  * **<color #00a2e8>Official Name</color>**: CD52 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1043|1043]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31358|P31358]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD52&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD52|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/114280|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in carrying and orienting carbohydrate, as well as having a more specific role.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|respiratory burst|
|sperm midpiece|
|intrinsic component of plasma membrane|
|anchored component of membrane|
|positive regulation of cytosolic calcium ion concentration|
|regulation of cytosolic calcium ion concentration|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|cellular metal ion homeostasis|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cellular homeostasis|
|chemical homeostasis|
|homeostatic process|
|extracellular region|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.51|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.86|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-1.81|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|-1.77|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.72|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|1.75|
|[[:results:exp433|LJH685 50μM R08 exp433]]|1.81|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.82|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.96|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|2.02|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|2.22|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|2.29|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.32|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|2.4|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|2.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14891
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.16 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD52 Expression in NALM6 Cells: 1.16'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>