======= CD86 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD86
  * **<color #00a2e8>Official Name</color>**: CD86 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=942|942]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P42081|P42081]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD86&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD86|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601020|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|V-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of lymphotoxin A production|
|regulation of lymphotoxin A production|
|positive regulation of lymphotoxin A biosynthetic process|
|regulation of lymphotoxin A biosynthetic process|
|positive regulation of interleukin-4 biosynthetic process|
|regulation of interleukin-4 biosynthetic process|
|positive regulation of T-helper 2 cell differentiation|
|regulation of T-helper 2 cell differentiation|
|positive regulation of interleukin-2 biosynthetic process|
|positive regulation of type 2 immune response|
|regulation of interleukin-2 biosynthetic process|
|positive regulation of T-helper cell differentiation|
|positive regulation of interleukin-4 production|
|regulation of interleukin-4 production|
|positive regulation of CD4-positive, alpha-beta T cell differentiation|
|regulation of type 2 immune response|
|positive regulation of interleukin-2 production|
|regulation of T-helper cell differentiation|
|positive regulation of CD4-positive, alpha-beta T cell activation|
|coreceptor activity|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|positive regulation of alpha-beta T cell differentiation|
|regulation of interleukin-2 production|
|T cell costimulation|
|lymphocyte costimulation|
|negative regulation of T cell proliferation|
|positive regulation of alpha-beta T cell activation|
|regulation of CD4-positive, alpha-beta T cell activation|
|regulation of alpha-beta T cell differentiation|
|positive regulation of cytokine biosynthetic process|
|negative regulation of lymphocyte proliferation|
|negative regulation of mononuclear cell proliferation|
|virus receptor activity|
|negative regulation of leukocyte proliferation|
|positive regulation of T cell differentiation|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|viral entry into host cell|
|positive regulation of T cell proliferation|
|entry into host|
|entry into host cell|
|regulation of cytokine biosynthetic process|
|negative regulation of T cell activation|
|negative regulation of leukocyte cell-cell adhesion|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte proliferation|
|regulation of T cell differentiation|
|negative regulation of lymphocyte activation|
|positive regulation of leukocyte differentiation|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of T cell proliferation|
|interaction with host|
|positive regulation of protein kinase B signaling|
|regulation of lymphocyte differentiation|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|cellular response to lipopolysaccharide|
|positive regulation of hemopoiesis|
|cellular response to molecule of bacterial origin|
|negative regulation of cell activation|
|viral life cycle|
|positive regulation of T cell activation|
|signaling receptor activity|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|cellular response to biotic stimulus|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of protein kinase B signaling|
|regulation of leukocyte proliferation|
|positive regulation of cell-cell adhesion|
|negative regulation of cell adhesion|
|regulation of leukocyte differentiation|
|regulation of leukocyte cell-cell adhesion|
|response to lipopolysaccharide|
|regulation of T cell activation|
|response to molecule of bacterial origin|
|positive regulation of lymphocyte activation|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of immune effector process|
|regulation of lymphocyte activation|
|cellular response to lipid|
|regulation of leukocyte activation|
|adaptive immune response|
|cell surface|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|response to lipid|
|positive regulation of immune response|
|positive regulation of cell population proliferation|
|positive regulation of cell differentiation|
|cellular response to cytokine stimulus|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|response to cytokine|
|positive regulation of immune system process|
|regulation of immune response|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|positive regulation of developmental process|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-2.45|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-2.27|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-1.98|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.73|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.72|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-1.71|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.73|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17200
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.38 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD86 Expression in NALM6 Cells: -2.38'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>