======= CD9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD9
  * **<color #00a2e8>Official Name</color>**: CD9 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=928|928]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P21926|P21926]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/143030|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins are cell surface glycoproteins with four transmembrane domains that form multimeric complexes with other cell surface proteins. The encoded protein functions in many cellular processes including differentiation, adhesion, and signal transduction, and expression of this gene plays a critical role in the suppression of cancer cell motility and metastasis. [provided by RefSeq, Jan 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion. {ECO:0000269|PubMed:14575715, ECO:0000269|PubMed:7511626, ECO:0000269|PubMed:8478605}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tetraspannin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|myoblast fusion involved in skeletal muscle regeneration|
|paranodal junction assembly|
|myotube differentiation involved in skeletal muscle regeneration|
|response to water deprivation|
|negative regulation of platelet aggregation|
|response to water|
|negative regulation of homotypic cell-cell adhesion|
|fusion of sperm to egg plasma membrane involved in single fertilization|
|platelet alpha granule membrane|
|cellular response to low-density lipoprotein particle stimulus|
|regulation of platelet aggregation|
|myelin assembly|
|negative regulation of platelet activation|
|plasma membrane fusion|
|myoblast fusion|
|regulation of homotypic cell-cell adhesion|
|response to lipoprotein particle|
|cellular response to lipoprotein particle stimulus|
|regulation of platelet activation|
|clathrin-coated endocytic vesicle membrane|
|skeletal muscle tissue regeneration|
|cell-cell fusion|
|syncytium formation by plasma membrane fusion|
|regulation of macrophage migration|
|syncytium formation|
|oligodendrocyte development|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|sperm-egg recognition|
|negative regulation of coagulation|
|extracellular vesicle|
|myotube differentiation|
|receptor internalization|
|tissue regeneration|
|endocytic vesicle membrane|
|oligodendrocyte differentiation|
|cell-cell recognition|
|negative regulation of wound healing|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|negative regulation of response to wounding|
|cellular component assembly involved in morphogenesis|
|cell-cell junction assembly|
|receptor metabolic process|
|myelination|
|glial cell development|
|ensheathment of neurons|
|axon ensheathment|
|platelet degranulation|
|integrin binding|
|membrane fusion|
|platelet activation|
|regulation of wound healing|
|cell-cell junction organization|
|single fertilization|
|regeneration|
|regulation of response to wounding|
|cell junction assembly|
|fertilization|
|glial cell differentiation|
|negative regulation of cell-cell adhesion|
|regulation of leukocyte migration|
|negative regulation of cell activation|
|striated muscle cell differentiation|
|gliogenesis|
|cell junction organization|
|receptor-mediated endocytosis|
|cell recognition|
|muscle cell differentiation|
|negative regulation of cell adhesion|
|blood coagulation|
|coagulation|
|hemostasis|
|negative regulation of cellular component movement|
|apical plasma membrane|
|response to acid chemical|
|cellular process involved in reproduction in multicellular organism|
|negative regulation of response to external stimulus|
|developmental growth|
|growth|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|focal adhesion|
|muscle structure development|
|wound healing|
|regulation of body fluid levels|
|response to inorganic substance|
|endocytosis|
|response to wounding|
|regulation of cell activation|
|import into cell|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulated exocytosis|
|brain development|
|head development|
|exocytosis|
|cellular component morphogenesis|
|sexual reproduction|
|multicellular organism reproduction|
|regulation of cell migration|
|membrane organization|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|central nervous system development|
|regulation of locomotion|
|multi-organism reproductive process|
|regulation of cellular component movement|
|response to organonitrogen compound|
|secretion by cell|
|export from cell|
|cell activation|
|response to nitrogen compound|
|regulation of response to external stimulus|
|secretion|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|regulation of response to stress|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|regulation of immune system process|
|tissue development|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.73|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.77|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.85|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.98|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.49|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|3.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17861
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD9 Expression in NALM6 Cells: 8.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>