======= CDK5RAP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDK5RAP3
  * **<color #00a2e8>Official Name</color>**: CDK5 regulatory subunit associated protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80279|80279]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96JB5|Q96JB5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDK5RAP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDK5RAP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608202|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629). {ECO:0000269|PubMed:12054757, ECO:0000269|PubMed:12737517, ECO:0000269|PubMed:15790566, ECO:0000269|PubMed:16173922, ECO:0000269|PubMed:17785205, ECO:0000269|PubMed:19223857, ECO:0000269|PubMed:20228063, ECO:0000269|PubMed:21283629, ECO:0000269|PubMed:23152784, ECO:0000269|PubMed:23478299}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF773|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein ufmylation|
|MDM2/MDM4 family protein binding|
|negative regulation of protein kinase activity by regulation of protein phosphorylation|
|mitotic G2 DNA damage checkpoint|
|positive regulation of signal transduction by p53 class mediator|
|mitogen-activated protein kinase binding|
|ubiquitin-like protein ligase binding|
|apoptotic nuclear changes|
|cellular component disassembly involved in execution phase of apoptosis|
|mitotic G2/M transition checkpoint|
|NF-kappaB binding|
|G2 DNA damage checkpoint|
|cyclin binding|
|execution phase of apoptosis|
|negative regulation of MAP kinase activity|
|positive regulation of protein localization to nucleus|
|negative regulation of NF-kappaB transcription factor activity|
|negative regulation of cellular protein catabolic process|
|negative regulation of G2/M transition of mitotic cell cycle|
|mitotic DNA damage checkpoint|
|positive regulation of ubiquitin-dependent protein catabolic process|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|negative regulation of cell cycle G2/M phase transition|
|regulation of cyclin-dependent protein kinase activity|
|mitotic DNA integrity checkpoint|
|endoplasmic reticulum unfolded protein response|
|positive regulation of protein ubiquitination|
|regulation of protein localization to nucleus|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|cellular response to unfolded protein|
|DNA damage checkpoint|
|negative regulation of protein serine/threonine kinase activity|
|negative regulation of protein catabolic process|
|positive regulation of protein modification by small protein conjugation or removal|
|positive regulation of cellular protein catabolic process|
|DNA integrity checkpoint|
|cellular response to topologically incorrect protein|
|regulation of ubiquitin-dependent protein catabolic process|
|mitotic cell cycle checkpoint|
|negative regulation of DNA-binding transcription factor activity|
|response to unfolded protein|
|negative regulation of MAPK cascade|
|regulation of phosphatase activity|
|regulation of signal transduction by p53 class mediator|
|response to topologically incorrect protein|
|cell cycle checkpoint|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of protein ubiquitination|
|regulation of cell cycle G2/M phase transition|
|regulation of dephosphorylation|
|negative regulation of mitotic cell cycle phase transition|
|positive regulation of protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|negative regulation of protein kinase activity|
|regulation of protein modification by small protein conjugation or removal|
|negative regulation of cell cycle phase transition|
|negative regulation of kinase activity|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|response to endoplasmic reticulum stress|
|negative regulation of transferase activity|
|negative regulation of mitotic cell cycle|
|negative regulation of catabolic process|
|microtubule|
|positive regulation of cellular protein localization|
|negative regulation of cell cycle process|
|regulation of MAP kinase activity|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|cellular component disassembly|
|negative regulation of protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|regulation of DNA-binding transcription factor activity|
|positive regulation of catabolic process|
|negative regulation of phosphorylation|
|regulation of cell cycle phase transition|
|protein kinase binding|
|centrosome|
|negative regulation of intracellular signal transduction|
|regulation of protein serine/threonine kinase activity|
|regulation of cellular protein localization|
|cell population proliferation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|protein-containing complex|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|regulation of neuron differentiation|
|mitotic cell cycle|
|regulation of proteolysis|
|brain development|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|head development|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|regulation of cellular catabolic process|
|nucleolus|
|regulation of kinase activity|
|regulation of cellular localization|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|regulation of transferase activity|
|central nervous system development|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|cell cycle process|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cell death|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.96|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.7|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4080
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.35 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDK5RAP3 Expression in NALM6 Cells: 7.35'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>