======= CEBPA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CEBPA
  * **<color #00a2e8>Official Name</color>**: CCAAT enhancer binding protein alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1050|1050]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49715|P49715]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CEBPA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CEBPA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/116897|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes (PubMed:11242107). During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung (By similarity). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (By similarity). To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Downregulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters. Proliferation arrest also depends on a functional binding to SWI/SNF complex (PubMed:14660596). In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC. To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites (By similarity). {ECO:0000250|UniProtKB:P05554, ECO:0000250|UniProtKB:P53566, ECO:0000269|PubMed:11242107, ECO:0000269|PubMed:14660596}. Isoform 4: Directly and specifically enhances ribosomal DNA transcription interacting with RNA polymerase I-specific cofactors and inducing histone acetylation. {ECO:0000269|PubMed:20075868}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|bZIP 2|
|bZIP 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of transcription by RNA polymerase III|
|urea cycle|
|urea metabolic process|
|nitrogen cycle metabolic process|
|white fat cell differentiation|
|cellular response to lithium ion|
|interleukin-6-mediated signaling pathway|
|granulocyte differentiation|
|response to lithium ion|
|regulation of transcription by RNA polymerase III|
|macrophage differentiation|
|positive regulation of macrophage activation|
|brown fat cell differentiation|
|negative regulation of cyclin-dependent protein serine/threonine kinase activity|
|negative regulation of cyclin-dependent protein kinase activity|
|cellular response to interleukin-6|
|response to interleukin-6|
|regulation of macrophage activation|
|positive regulation of osteoblast differentiation|
|positive regulation of fat cell differentiation|
|RNA polymerase II transcription factor complex|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|positive regulation of ossification|
|embryonic placenta development|
|kinase binding|
|positive regulation of ubiquitin-dependent protein catabolic process|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|positive regulation of proteasomal protein catabolic process|
|fat cell differentiation|
|myeloid leukocyte differentiation|
|regulation of osteoblast differentiation|
|cholesterol metabolic process|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of fat cell differentiation|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|liver development|
|Notch signaling pathway|
|hepaticobiliary system development|
|secondary alcohol metabolic process|
|negative regulation of protein serine/threonine kinase activity|
|lipid homeostasis|
|sterol metabolic process|
|positive regulation of inflammatory response|
|positive regulation of cellular protein catabolic process|
|placenta development|
|regulation of ubiquitin-dependent protein catabolic process|
|cell maturation|
|lung development|
|respiratory tube development|
|regulation of proteasomal protein catabolic process|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of ossification|
|cellular response to metal ion|
|inner ear development|
|respiratory system development|
|transcription factor complex|
|positive regulation of protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|transcription regulatory region DNA binding|
|cellular response to inorganic substance|
|myeloid cell differentiation|
|ear development|
|negative regulation of protein kinase activity|
|developmental maturation|
|cellular response to tumor necrosis factor|
|negative regulation of kinase activity|
|regulation of cellular protein catabolic process|
|steroid metabolic process|
|response to tumor necrosis factor|
|negative regulation of transferase activity|
|transcription coactivator activity|
|alcohol metabolic process|
|leukocyte differentiation|
|transcription factor binding|
|regulation of inflammatory response|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|response to metal ion|
|in utero embryonic development|
|regulation of protein catabolic process|
|positive regulation of leukocyte activation|
|negative regulation of protein phosphorylation|
|gland development|
|positive regulation of cell activation|
|generation of precursor metabolites and energy|
|reproductive structure development|
|reproductive system development|
|positive regulation of catabolic process|
|embryonic organ development|
|mitochondrion organization|
|negative regulation of phosphorylation|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|organic hydroxy compound metabolic process|
|positive regulation of defense response|
|transcription by RNA polymerase II|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|regulation of protein serine/threonine kinase activity|
|amide biosynthetic process|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|sensory organ development|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|regulation of cell activation|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|immune system development|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|developmental process involved in reproduction|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|DNA-binding transcription factor activity|
|intracellular membrane-bounded organelle|
|viral process|
|regulation of proteolysis|
|regulation of defense response|
|symbiotic process|
|cellular amide metabolic process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|tube development|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|regulation of kinase activity|
|protein homodimerization activity|
|response to organic cyclic compound|
|positive regulation of cell differentiation|
|embryo development|
|regulation of transferase activity|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|negative regulation of cellular protein metabolic process|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|negative regulation of molecular function|
|positive regulation of immune system process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|regulation of immune system process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-2.13|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.89|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|2/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3780
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CEBPA Expression in NALM6 Cells: 0.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>