======= CENPA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CENPA
  * **<color #00a2e8>Official Name</color>**: centromere protein A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1058|1058]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49450|P49450]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CENPA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CENPA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/117139|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:7962047, PubMed:9024683, PubMed:11756469, PubMed:14667408, PubMed:15702419, PubMed:15475964, PubMed:15282608, PubMed:17651496, PubMed:19114591, PubMed:27499292, PubMed:20739937). Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:27499292, PubMed:26878239). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15475964, PubMed:15282608, PubMed:26878239, PubMed:20739937, PubMed:21478274). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292). {ECO:0000269|PubMed:11756469, ECO:0000269|PubMed:14667408, ECO:0000269|PubMed:15282608, ECO:0000269|PubMed:15475964, ECO:0000269|PubMed:15702419, ECO:0000269|PubMed:17651496, ECO:0000269|PubMed:18072184, ECO:0000269|PubMed:19114591, ECO:0000269|PubMed:21478274, ECO:0000269|PubMed:23818633, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26878239, ECO:0000269|PubMed:27499292, ECO:0000269|PubMed:7962047, ECO:0000269|PubMed:9024683, ECO:0000305|PubMed:20739937}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Histone|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|condensed chromosome inner kinetochore|
|nuclear pericentric heterochromatin|
|condensed nuclear chromosome kinetochore|
|kinetochore assembly|
|condensed nuclear chromosome, centromeric region|
|nuclear nucleosome|
|protein localization to chromosome, centromeric region|
|kinetochore organization|
|establishment of mitotic spindle orientation|
|CENP-A containing chromatin organization|
|CENP-A containing nucleosome assembly|
|establishment of mitotic spindle localization|
|chromatin remodeling at centromere|
|establishment of spindle orientation|
|centromere complex assembly|
|DNA replication-independent nucleosome assembly|
|DNA replication-independent nucleosome organization|
|establishment of spindle localization|
|nucleosomal DNA binding|
|histone exchange|
|spindle localization|
|chromosome, centromeric region|
|protein localization to chromosome|
|mitotic cytokinesis|
|nucleosome|
|ATP-dependent chromatin remodeling|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|microtubule cytoskeleton organization involved in mitosis|
|nucleosome assembly|
|establishment of cell polarity|
|chromatin assembly|
|chromatin assembly or disassembly|
|nucleosome organization|
|chromatin remodeling|
|DNA packaging|
|establishment or maintenance of cell polarity|
|protein-DNA complex assembly|
|protein-DNA complex subunit organization|
|DNA conformation change|
|establishment of organelle localization|
|chromatin binding|
|microtubule cytoskeleton organization|
|protein heterodimerization activity|
|cell division|
|organelle localization|
|mitotic cell cycle process|
|microtubule-based process|
|mitotic cell cycle|
|chromatin organization|
|viral process|
|protein localization to organelle|
|organelle assembly|
|symbiotic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|cell cycle process|
|chromosome organization|
|cytoskeleton organization|
|cell cycle|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of localization in cell|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2.46|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-2.41|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-2.29|
|[[:results:exp302|35°C R06 exp302]]|-1.87|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.85|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.82|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c14orf80|C14orf80]]|0.464|
|[[:human genes:g:gemin8|GEMIN8]]|0.458|
|[[:human genes:t:tubd1|TUBD1]]|0.434|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 368/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|15/28|
|blood|10/28|
|bone|8/25|
|breast|13/33|
|central nervous system|28/56|
|cervix|4/4|
|colorectal|11/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|6/15|
|kidney|8/21|
|liver|7/20|
|lung|43/75|
|lymphocyte|8/14|
|ovary|9/26|
|pancreas|17/24|
|peripheral nervous system|10/16|
|plasma cell|9/15|
|prostate|0/1|
|skin|9/24|
|soft tissue|2/7|
|thyroid|2/2|
|upper aerodigestive|18/22|
|urinary tract|21/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 197
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CENPA Expression in NALM6 Cells: 4.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>