======= CENPT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CENPT
  * **<color #00a2e8>Official Name</color>**: centromere protein T
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80152|80152]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96BT3|Q96BT3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CENPT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CENPT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611510|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome- associated complex that binds specifically to histone H3- containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:21529714, ECO:0000269|PubMed:21695110}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|kinetochore assembly|
|kinetochore organization|
|CENP-A containing chromatin organization|
|CENP-A containing nucleosome assembly|
|chromatin remodeling at centromere|
|centromere complex assembly|
|DNA replication-independent nucleosome assembly|
|DNA replication-independent nucleosome organization|
|histone exchange|
|chromosome, centromeric region|
|ATP-dependent chromatin remodeling|
|kinetochore|
|condensed chromosome kinetochore|
|nucleosome assembly|
|chromatin assembly|
|chromatin assembly or disassembly|
|nucleosome organization|
|chromatin remodeling|
|DNA packaging|
|protein-DNA complex assembly|
|protein-DNA complex subunit organization|
|chromosome segregation|
|nuclear body|
|DNA conformation change|
|protein heterodimerization activity|
|cell division|
|mitotic cell cycle|
|chromatin organization|
|organelle assembly|
|cellular protein-containing complex assembly|
|chromosome organization|
|cell cycle|
|DNA binding|
|protein-containing complex assembly|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-2.32|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.23|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.97|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.93|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.87|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.87|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-1.85|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.82|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.8|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-1.76|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 179/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|10/28|
|blood|8/28|
|bone|8/26|
|breast|7/33|
|central nervous system|8/56|
|cervix|0/4|
|colorectal|5/17|
|esophagus|3/13|
|fibroblast|1/1|
|gastric|3/16|
|kidney|3/21|
|liver|5/20|
|lung|15/75|
|lymphocyte|6/16|
|ovary|8/26|
|pancreas|8/24|
|peripheral nervous system|8/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|4/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|6/22|
|urinary tract|8/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2485
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CENPT Expression in NALM6 Cells: 6.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>