======= CENPV =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CENPV
  * **<color #00a2e8>Official Name</color>**: centromere protein V
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=201161|201161]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z7K6|Q7Z7K6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CENPV&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CENPV|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608139|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis. {ECO:0000269|PubMed:18772885}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GFA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pericentric heterochromatin assembly|
|carbon-sulfur lyase activity|
|heterochromatin assembly|
|heterochromatin organization|
|spindle midzone|
|chromatin remodeling at centromere|
|centromere complex assembly|
|positive regulation of cytokinesis|
|kinetochore|
|positive regulation of cell division|
|regulation of cytokinesis|
|condensed chromosome kinetochore|
|chromatin assembly|
|microtubule cytoskeleton|
|chromatin assembly or disassembly|
|chromatin remodeling|
|regulation of cell division|
|ameboidal-type cell migration|
|DNA packaging|
|protein-DNA complex assembly|
|protein-DNA complex subunit organization|
|positive regulation of cell cycle process|
|DNA conformation change|
|regulation of chromosome organization|
|positive regulation of cell cycle|
|cell division|
|chromatin organization|
|regulation of cell cycle process|
|molecular function|
|cellular protein-containing complex assembly|
|cell migration|
|chromosome organization|
|localization of cell|
|cell motility|
|regulation of cell cycle|
|regulation of organelle organization|
|locomotion|
|cell cycle|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.87|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3686
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CENPV Expression in NALM6 Cells: 5.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>