======= CH25H =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CH25H
  * **<color #00a2e8>Official Name</color>**: cholesterol 25-hydroxylase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9023|9023]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95992|O95992]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CH25H&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CH25H|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604551|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:9852097). Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation. {ECO:0000250|UniProtKB:Q9Z0F5, ECO:0000269|PubMed:9852097}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FA hydroxylase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cholesterol 25-hydroxylase activity|
|C-4 methylsterol oxidase activity|
|B cell chemotaxis|
|bile acid biosynthetic process|
|steroid hydroxylase activity|
|bile acid metabolic process|
|lymphocyte chemotaxis|
|sterol biosynthetic process|
|lymphocyte migration|
|cholesterol metabolic process|
|steroid biosynthetic process|
|secondary alcohol metabolic process|
|iron ion binding|
|sterol metabolic process|
|leukocyte chemotaxis|
|monocarboxylic acid biosynthetic process|
|organic hydroxy compound biosynthetic process|
|cell chemotaxis|
|steroid metabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|alcohol metabolic process|
|leukocyte migration|
|organic hydroxy compound metabolic process|
|monocarboxylic acid metabolic process|
|chemotaxis|
|taxis|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|carboxylic acid metabolic process|
|endoplasmic reticulum membrane|
|cell migration|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|localization of cell|
|cell motility|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|locomotion|
|movement of cell or subcellular component|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4338
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CH25H Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>