======= CHCHD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHCHD1
  * **<color #00a2e8>Official Name</color>**: coiled-coil-helix-coiled-coil-helix domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=118487|118487]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96BP2|Q96BP2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHCHD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHCHD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608842|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CHCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial ribosome|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|fibrillar center|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp11|CCCP 1μM R00 exp11]]|-2.18|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-2.08|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-1.91|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.7|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.73|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.86|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|1.89|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.89|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.91|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.14|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.25|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:acad9|ACAD9]]|0.597|
|[[:human genes:m:mto1|MTO1]]|0.594|
|[[:human genes:g:grsf1|GRSF1]]|0.585|
|[[:human genes:n:ndufb11|NDUFB11]]|0.583|
|[[:human genes:m:mtg1|MTG1]]|0.577|
|[[:human genes:n:ndufa2|NDUFA2]]|0.575|
|[[:human genes:m:mettl17|METTL17]]|0.575|
|[[:human genes:m:mrpl21|MRPL21]]|0.569|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.567|
|[[:human genes:n:ndufs2|NDUFS2]]|0.567|
|[[:human genes:n:ndufa11|NDUFA11]]|0.566|
|[[:human genes:m:mrpl45|MRPL45]]|0.565|
|[[:human genes:n:ndufa1|NDUFA1]]|0.561|
|[[:human genes:g:gfm2|GFM2]]|0.56|
|[[:human genes:m:mtg2|MTG2]]|0.557|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.553|
|[[:human genes:n:ndufa3|NDUFA3]]|0.549|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.543|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.542|
|[[:human genes:n:ndufc2|NDUFC2]]|0.542|
|[[:human genes:q:qrsl1|QRSL1]]|0.54|
|[[:human genes:s:ssbp1|SSBP1]]|0.537|
|[[:human genes:n:ndufb7|NDUFB7]]|0.537|
|[[:human genes:m:mrps21|MRPS21]]|0.537|
|[[:human genes:f:fastkd2|FASTKD2]]|0.536|
|[[:human genes:m:malsu1|MALSU1]]|0.535|
|[[:human genes:n:ndufb10|NDUFB10]]|0.533|
|[[:human genes:m:mrpl47|MRPL47]]|0.533|
|[[:human genes:m:mrps5|MRPS5]]|0.531|
|[[:human genes:m:mrpl53|MRPL53]]|0.531|
|[[:human genes:m:mrps34|MRPS34]]|0.531|
|[[:human genes:f:ftsj2|FTSJ2]]|0.529|
|[[:human genes:n:ndufb9|NDUFB9]]|0.527|
|[[:human genes:p:polrmt|POLRMT]]|0.519|
|[[:human genes:p:pet117|PET117]]|0.519|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.517|
|[[:human genes:r:rpusd3|RPUSD3]]|0.511|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.511|
|[[:human genes:g:gfm1|GFM1]]|0.503|
|[[:human genes:m:mrpl49|MRPL49]]|0.502|
|[[:human genes:c:c12orf65|C12orf65]]|0.501|
|[[:human genes:m:mrp63|MRP63]]|0.501|
|[[:human genes:m:mrps12|MRPS12]]|0.496|
|[[:human genes:n:nars2|NARS2]]|0.495|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.494|
|[[:human genes:r:rpusd4|RPUSD4]]|0.493|
|[[:human genes:m:mrpl23|MRPL23]]|0.491|
|[[:human genes:n:ndufs7|NDUFS7]]|0.49|
|[[:human genes:c:coq7|COQ7]]|0.49|
|[[:human genes:n:ndufb6|NDUFB6]]|0.486|
|[[:human genes:e:ecsit|ECSIT]]|0.483|
|[[:human genes:a:aifm1|AIFM1]]|0.482|
|[[:human genes:m:mrps26|MRPS26]]|0.482|
|[[:human genes:m:mrpl3|MRPL3]]|0.481|
|[[:human genes:m:mrps6|MRPS6]]|0.481|
|[[:human genes:n:ndufs8|NDUFS8]]|0.481|
|[[:human genes:p:ptcd3|PTCD3]]|0.481|
|[[:human genes:p:pet112|PET112]]|0.481|
|[[:human genes:n:nubpl|NUBPL]]|0.479|
|[[:human genes:e:eral1|ERAL1]]|0.478|
|[[:human genes:p:pnpt1|PNPT1]]|0.478|
|[[:human genes:r:rbfa|RBFA]]|0.478|
|[[:human genes:n:ndufv1|NDUFV1]]|0.478|
|[[:human genes:m:mrpl13|MRPL13]]|0.477|
|[[:human genes:t:tars2|TARS2]]|0.476|
|[[:human genes:m:mrps2|MRPS2]]|0.476|
|[[:human genes:m:mrpl15|MRPL15]]|0.476|
|[[:human genes:n:ndufb5|NDUFB5]]|0.475|
|[[:human genes:m:mrps14|MRPS14]]|0.475|
|[[:human genes:p:pars2|PARS2]]|0.472|
|[[:human genes:m:mterfd1|MTERFD1]]|0.472|
|[[:human genes:c:cox6b1|COX6B1]]|0.472|
|[[:human genes:c:coa3|COA3]]|0.472|
|[[:human genes:m:mrpl44|MRPL44]]|0.47|
|[[:human genes:m:mrpl4|MRPL4]]|0.47|
|[[:human genes:n:ndufa10|NDUFA10]]|0.469|
|[[:human genes:c:coq2|COQ2]]|0.469|
|[[:human genes:m:mrps16|MRPS16]]|0.469|
|[[:human genes:c:cox16|COX16]]|0.469|
|[[:human genes:n:ndufb2|NDUFB2]]|0.469|
|[[:human genes:d:ddx28|DDX28]]|0.468|
|[[:human genes:t:trub2|TRUB2]]|0.468|
|[[:human genes:n:ndufc1|NDUFC1]]|0.467|
|[[:human genes:m:mtif2|MTIF2]]|0.467|
|[[:human genes:w:wbscr16|WBSCR16]]|0.466|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.466|
|[[:human genes:f:fastkd5|FASTKD5]]|0.465|
|[[:human genes:f:fars2|FARS2]]|0.465|
|[[:human genes:l:lars2|LARS2]]|0.464|
|[[:human genes:m:mrpl43|MRPL43]]|0.464|
|[[:human genes:m:mrps25|MRPS25]]|0.461|
|[[:human genes:c:cars2|CARS2]]|0.461|
|[[:human genes:s:selrc1|SELRC1]]|0.461|
|[[:human genes:m:mrpl1|MRPL1]]|0.46|
|[[:human genes:m:mipep|MIPEP]]|0.458|
|[[:human genes:m:mtpap|MTPAP]]|0.457|
|[[:human genes:m:mterfd2|MTERFD2]]|0.457|
|[[:human genes:i:iba57|IBA57]]|0.456|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.455|
|[[:human genes:d:dap3|DAP3]]|0.455|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.454|
|[[:human genes:a:aars2|AARS2]]|0.453|
|[[:human genes:m:mcat|MCAT]]|0.452|
|[[:human genes:n:ndufs5|NDUFS5]]|0.451|
|[[:human genes:m:mrps9|MRPS9]]|0.449|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.449|
|[[:human genes:t:tmem261|TMEM261]]|0.447|
|[[:human genes:p:polg2|POLG2]]|0.447|
|[[:human genes:r:rars2|RARS2]]|0.445|
|[[:human genes:m:mrps22|MRPS22]]|0.444|
|[[:human genes:s:sco2|SCO2]]|0.443|
|[[:human genes:m:mrps27|MRPS27]]|0.443|
|[[:human genes:c:clpp|CLPP]]|0.442|
|[[:human genes:t:tfb1m|TFB1M]]|0.441|
|[[:human genes:c:coq4|COQ4]]|0.44|
|[[:human genes:m:mrps24|MRPS24]]|0.436|
|[[:human genes:m:mrpl22|MRPL22]]|0.435|
|[[:human genes:s:sfxn4|SFXN4]]|0.435|
|[[:human genes:y:yars2|YARS2]]|0.434|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.434|
|[[:human genes:v:vars2|VARS2]]|0.433|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.432|
|[[:human genes:m:mrpl55|MRPL55]]|0.431|
|[[:human genes:s:slc25a3|SLC25A3]]|0.431|
|[[:human genes:m:mrpl17|MRPL17]]|0.431|
|[[:human genes:a:atp5sl|ATP5SL]]|0.431|
|[[:human genes:t:tufm|TUFM]]|0.431|
|[[:human genes:c:c17orf89|C17orf89]]|0.43|
|[[:human genes:p:pde12|PDE12]]|0.429|
|[[:human genes:n:ndufb4|NDUFB4]]|0.428|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.427|
|[[:human genes:m:mrpl42|MRPL42]]|0.426|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.426|
|[[:human genes:f:foxred1|FOXRED1]]|0.426|
|[[:human genes:g:glrx5|GLRX5]]|0.424|
|[[:human genes:m:mrps33|MRPS33]]|0.424|
|[[:human genes:t:tomm20|TOMM20]]|0.424|
|[[:human genes:n:ndufv2|NDUFV2]]|0.423|
|[[:human genes:m:mrpl12|MRPL12]]|0.421|
|[[:human genes:s:sars2|SARS2]]|0.42|
|[[:human genes:d:dars2|DARS2]]|0.42|
|[[:human genes:m:mrpl37|MRPL37]]|0.418|
|[[:human genes:m:mars2|MARS2]]|0.415|
|[[:human genes:m:mrps35|MRPS35]]|0.414|
|[[:human genes:m:mrpl20|MRPL20]]|0.414|
|[[:human genes:n:ndufs1|NDUFS1]]|0.413|
|[[:human genes:d:dhx30|DHX30]]|0.413|
|[[:human genes:n:ndufa8|NDUFA8]]|0.412|
|[[:human genes:n:ndufb3|NDUFB3]]|0.412|
|[[:human genes:m:mrpl39|MRPL39]]|0.41|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.409|
|[[:human genes:m:mrpl24|MRPL24]]|0.408|
|[[:human genes:c:cox15|COX15]]|0.408|
|[[:human genes:c:cox17|COX17]]|0.407|
|[[:human genes:n:ndufa5|NDUFA5]]|0.406|
|[[:human genes:m:mrpl46|MRPL46]]|0.405|
|[[:human genes:h:hars2|HARS2]]|0.404|
|[[:human genes:n:ndufa6|NDUFA6]]|0.404|
|[[:human genes:p:polg|POLG]]|0.404|
|[[:human genes:m:mrps23|MRPS23]]|0.4|
|[[:human genes:c:coa6|COA6]]|0.4|
|[[:human genes:m:mrpl41|MRPL41]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 217/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|9/28|
|blood|10/28|
|bone|7/26|
|breast|9/33|
|central nervous system|12/56|
|cervix|3/4|
|colorectal|5/17|
|esophagus|7/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|4/21|
|liver|6/20|
|lung|25/75|
|lymphocyte|4/16|
|ovary|6/26|
|pancreas|4/24|
|peripheral nervous system|8/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|7/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|9/22|
|urinary tract|4/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 741
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHCHD1 Expression in NALM6 Cells: 5.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>