======= CHMP1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHMP1A
  * **<color #00a2e8>Official Name</color>**: charged multivesicular body protein 1A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5119|5119]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HD42|Q9HD42]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHMP1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHMP1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164010|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the CHMP/Chmp family of proteins which are involved in multivesicular body sorting of proteins to the interiors of lysosomes. The initial prediction of the protein sequence encoded by this gene suggested that the encoded protein was a metallopeptidase. The nomenclature has been updated recently to reflect the correct biological function of this encoded protein. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing. {ECO:0000269|PubMed:11559747, ECO:0000269|PubMed:11559748, ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:23045692}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Snf7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ESCRT complex disassembly|
|ESCRT III complex disassembly|
|ESCRT III complex|
|late endosome to vacuole transport|
|mitotic chromosome condensation|
|midbody abscission|
|mitotic cytokinetic process|
|viral budding via host ESCRT complex|
|regulation of mitotic spindle assembly|
|endosome transport via multivesicular body sorting pathway|
|viral budding|
|condensed nuclear chromosome|
|regulation of spindle assembly|
|multivesicular body assembly|
|multivesicular body organization|
|multivesicular body|
|multivesicular body sorting pathway|
|cytokinetic process|
|virion assembly|
|regulation of mitotic spindle organization|
|regulation of spindle organization|
|chromosome condensation|
|regulation of centrosome duplication|
|mitotic metaphase plate congression|
|metaphase plate congression|
|regulation of centrosome cycle|
|metallopeptidase activity|
|mitotic cytokinesis|
|establishment of chromosome localization|
|chromosome localization|
|endomembrane system|
|endosome organization|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|mitotic sister chromatid segregation|
|nuclear matrix|
|nucleus organization|
|vacuolar transport|
|sister chromatid segregation|
|mitotic nuclear division|
|gene silencing|
|microtubule organizing center|
|regulation of mitotic nuclear division|
|DNA packaging|
|regulation of microtubule cytoskeleton organization|
|regulation of nuclear division|
|viral life cycle|
|nuclear chromosome segregation|
|regulation of organelle assembly|
|regulation of microtubule-based process|
|endosomal transport|
|protein-containing complex disassembly|
|protein domain specific binding|
|early endosome|
|chromosome segregation|
|nuclear division|
|DNA conformation change|
|vesicle organization|
|organelle fission|
|establishment of organelle localization|
|cellular component disassembly|
|endomembrane system organization|
|cell division|
|regulation of cytoskeleton organization|
|negative regulation of cell cycle|
|organelle localization|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|viral process|
|regulation of cell cycle process|
|organelle assembly|
|symbiotic process|
|interspecies interaction between organisms|
|zinc ion binding|
|membrane organization|
|protein homodimerization activity|
|regulation of cellular component biogenesis|
|cell cycle process|
|chromosome organization|
|identical protein binding|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|proteolysis|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|negative regulation of biosynthetic process|
|amide transport|
|establishment of protein localization|
|negative regulation of gene expression|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-2.1|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.06|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.97|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.96|
|[[:results:exp16|DABN 2μM R00 exp16]]|-1.89|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-1.71|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.82|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 35/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|1/25|
|breast|1/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/15|
|kidney|0/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|0/14|
|ovary|1/26|
|pancreas|5/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5267
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHMP1A Expression in NALM6 Cells: 5.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>