======= CHRNA4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHRNA4
  * **<color #00a2e8>Official Name</color>**: cholinergic receptor nicotinic alpha 4 subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1137|1137]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P43681|P43681]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHRNA4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHRNA4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/118504|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions. {ECO:0000269|PubMed:22361591}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Neur chan memb|
|Neur chan LBD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|behavioral response to nicotine|
|inhibitory postsynaptic potential|
|dopaminergic synapse|
|ligand-gated ion channel activity|
|acetylcholine-gated cation-selective channel activity|
|acetylcholine receptor activity|
|acetylcholine binding|
|acetylcholine-gated channel complex|
|exploration behavior|
|synaptic transmission, cholinergic|
|acetylcholine receptor signaling pathway|
|cellular response to acetylcholine|
|response to acetylcholine|
|neuromuscular synaptic transmission|
|postsynaptic signal transduction|
|regulation of dopamine secretion|
|respiratory gaseous exchange by respiratory system|
|extracellular ligand-gated ion channel activity|
|response to nicotine|
|membrane depolarization|
|integral component of presynaptic membrane|
|regulation of catecholamine secretion|
|excitatory postsynaptic potential|
|chemical synaptic transmission, postsynaptic|
|sensory perception of pain|
|regulation of synaptic vesicle exocytosis|
|signal transduction involved in cellular response to ammonium ion|
|regulation of amine transport|
|action potential|
|regulation of response to drug|
|regulation of postsynaptic membrane potential|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|cellular response to ammonium ion|
|regulation of neurotransmitter transport|
|adult behavior|
|B cell activation|
|regulation of regulated secretory pathway|
|response to ammonium ion|
|locomotory behavior|
|postsynaptic membrane|
|regulation of exocytosis|
|calcium ion transport|
|synapse|
|divalent metal ion transport|
|cognition|
|divalent inorganic cation transport|
|neuron projection|
|response to hypoxia|
|regulation of neurotransmitter levels|
|response to decreased oxygen levels|
|neuronal cell body|
|response to oxygen levels|
|lymphocyte activation|
|response to oxidative stress|
|external side of plasma membrane|
|cellular response to drug|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|dendrite|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|response to toxic substance|
|DNA repair|
|cell junction|
|regulation of vesicle-mediated transport|
|behavior|
|cellular response to hormone stimulus|
|metal ion transport|
|cellular response to nitrogen compound|
|regulation of ion transport|
|DNA metabolic process|
|regulation of secretion by cell|
|cellular response to DNA damage stimulus|
|regulation of secretion|
|cation transport|
|response to hormone|
|regulation of cellular localization|
|leukocyte activation|
|ion transmembrane transport|
|sensory perception|
|response to drug|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|cell-cell signaling|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|cellular response to stress|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp112|S-DABN 8μM R03 exp112]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10388
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHRNA4 Expression in NALM6 Cells: -2.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>