======= CLCN6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLCN6
  * **<color #00a2e8>Official Name</color>**: chloride voltage-gated channel 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1185|1185]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51797|P51797]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLCN6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLCN6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602726|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown. [provided by RefSeq, Mar 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CBS|
|Voltage CLC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|voltage-gated chloride channel activity|
|chloride transmembrane transporter activity|
|antiporter activity|
|cell volume homeostasis|
|transmembrane transporter activity|
|chloride transmembrane transport|
|chloride transport|
|inorganic anion transmembrane transport|
|inorganic anion transport|
|regulation of cell size|
|response to mechanical stimulus|
|endosome membrane|
|anion transmembrane transport|
|lysosomal membrane|
|regulation of cellular component size|
|regulation of anatomical structure size|
|anion transport|
|inorganic ion transmembrane transport|
|intracellular membrane-bounded organelle|
|cellular homeostasis|
|ion transmembrane transport|
|response to abiotic stimulus|
|transmembrane transport|
|ion transport|
|ATP binding|
|homeostatic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.95|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.95|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.99|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|2.07|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:copg1|COPG1]]|0.427|
|[[:human genes:c:copb2|COPB2]]|0.427|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.423|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.423|
|[[:human genes:p:pan3|PAN3]]|0.422|
|[[:human genes:u:utp3|UTP3]]|0.414|
|[[:human genes:r:rps2|RPS2]]|0.414|
|[[:human genes:m:mphosph10|MPHOSPH10]]|0.414|
|[[:human genes:z:znf655|ZNF655]]|0.412|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.403|
|[[:human genes:c:c14orf93|C14orf93]]|0.401|
|[[:human genes:r:rps3a|RPS3A]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2113
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLCN6 Expression in NALM6 Cells: 5.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>