======= CLIC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLIC1
  * **<color #00a2e8>Official Name</color>**: chloride intracellular channel 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1192|1192]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00299|O00299]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLIC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLIC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602872|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle. {ECO:0000269|PubMed:10834939, ECO:0000269|PubMed:11195932, ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:11940526, ECO:0000269|PubMed:11978800, ECO:0000269|PubMed:14613939, ECO:0000269|PubMed:9139710}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|platelet aggregation|
|voltage-gated ion channel activity|
|chloride channel complex|
|brush border|
|chloride channel activity|
|positive regulation of osteoblast differentiation|
|homotypic cell-cell adhesion|
|regulation of mitochondrial membrane potential|
|positive regulation of ossification|
|chloride transmembrane transport|
|chloride transport|
|inorganic anion transmembrane transport|
|regulation of osteoblast differentiation|
|platelet activation|
|blood microparticle|
|vesicle|
|inorganic anion transport|
|nuclear envelope|
|regulation of ossification|
|nuclear membrane|
|anion transmembrane transport|
|blood coagulation|
|coagulation|
|hemostasis|
|cadherin binding|
|regulation of membrane potential|
|regulation of ion transmembrane transport|
|wound healing|
|regulation of body fluid levels|
|cell-cell adhesion|
|regulation of transmembrane transport|
|response to wounding|
|anion transport|
|inorganic ion transmembrane transport|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|cell adhesion|
|biological adhesion|
|ion transmembrane transport|
|positive regulation of cell differentiation|
|cell activation|
|regulation of cell cycle|
|mitochondrion|
|transmembrane transport|
|positive regulation of developmental process|
|ion transport|
|extracellular space|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16563
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLIC1 Expression in NALM6 Cells: 7.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>